Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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Chemotherapy C: Antineoplastic Drugs<br />

68. Toxicity <strong>of</strong> nitrogen mustards can be decreased by:<br />

(a) Amifostine (DPG 2000)<br />

(b) Folinic acid<br />

(c) GM-CSF<br />

(d) MESNA<br />

69. Which one <strong>of</strong> the following alkaloids is used as anticancer<br />

agent? (MPPG 2007) (MPPG 2004)<br />

(a) Vincristine<br />

(b) Papaverine<br />

(c) Ephedrine<br />

(d) Atropine<br />

70. The antimalignancy drug which is potentially cardiotoxic<br />

is: (MPPG 2005)<br />

(a) Doxorubicin (RJ 2002)<br />

(b) Bleomycin (TN 2000)<br />

(c) Fluorouracil<br />

(d) Dacarbazine<br />

71. “Stocking and glove” neuropathy is seen in: (UP 2005)<br />

(a) Vinblastine<br />

(b) Paclitaxel<br />

(c) Etoposide<br />

(d) Mitoxantrone<br />

72. Which <strong>of</strong> the following anti-cancer drug is NOT<br />

‘S’-phase specific? (MH 2008)<br />

(a) Methotrexate<br />

(b) Mercaptopurine<br />

(c) Ifosfamide<br />

(d) Thioguanine<br />

73. All are alkylating agents except: (Bihar 2005)<br />

(a) Cyclophosphamide<br />

(b) Lomustine<br />

(c) Busulfan<br />

(d) Zalcitabine<br />

74. Cisplatin does not cause: (AP 2003)<br />

(a) Cardiomyopathy<br />

(b) Nephrotoxicity<br />

(c) Neuropathy<br />

(d) Tinnitus<br />

tahir99 - UnitedVRG<br />

75. Cyclophosphamide can cause: (AP 2003)<br />

(a) Hemorrhagic cystitis<br />

(b) Cardiomyopathy<br />

(c) Neuropathy<br />

(d) Convulsions<br />

76. Which <strong>of</strong> the following is not an early adverse effect <strong>of</strong><br />

methotrexate? (Kolkata 2009)<br />

(a) Hepatic fibrosis<br />

(b) Myelosupression<br />

(c) Nausea<br />

(d) Stomatitis<br />

77. Which <strong>of</strong> the following is not an antineoplastic<br />

antibiotic? (Kolkata 2009)<br />

(a) Actinomycin D<br />

(b) Doxorubicin<br />

(c) Bleomycin<br />

(d) Spiramycin<br />

78. Leucovorin rescue is related to: (Kolkata 2006)<br />

(a) Methotrexate toxicity<br />

(b) Cyclophosphamide toxicity<br />

(c) Oncovin toxicity<br />

(d) Cisplatin toxicity<br />

79. Which <strong>of</strong> the following causes peripheral neuritis?<br />

(a) Methotrexete (Kolkata 2007)<br />

(b) Vincristine<br />

(c) Busulfan<br />

(d) Cyclophosphamide<br />

80. Alkylating agengts include: (PGI June, 2002)<br />

(a) Doxorubicin<br />

(b) Chlorambucil<br />

(c) Vinblastine<br />

(d) Busulfan<br />

(e) Methotrexate<br />

New Drugs and Miscellaneous<br />

81. Which <strong>of</strong> the following is used to treat hormone-responsive<br />

breast cancer? (AIIMS May, 2012)<br />

(a) Adriamycin<br />

(b) Clomiphene citrate<br />

(c) Diethylstibestrol<br />

(d) Tamoxifen<br />

82. Which <strong>of</strong> the following is a radioprotector? (AI 2012)<br />

(a) Colony stimulating factor<br />

(b) Amifostine<br />

(c) Cisplatin<br />

(d) Methotrexate<br />

83. Use <strong>of</strong> tamoxifen in carcinoma <strong>of</strong> breast patients does<br />

not lead to the following side effects:(AIIMS May 2011)<br />

(a) Thromboembolic events<br />

(b) Endometrial carcinoma<br />

(c) Cataract<br />

(d) Cancer in opposite breast<br />

84. Thalidomide was once used for treating emesis <strong>of</strong><br />

pregnancy. Later it was withdrawn from market due<br />

to side effects. But it was reintro-duced for certain<br />

indications like multiple myeloma. All <strong>of</strong> the following<br />

are side effects <strong>of</strong> thalidomide except: (AI 2011)<br />

(a) Hypothyroidism<br />

(b) Diarrhea<br />

(c) Teratogenicity<br />

(d) Deep Vein Thrombosis<br />

Chemotherapy General C: <strong>Pharmacology</strong><br />

Antineoplastic Drugs<br />

655<br />

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