Review of Pharmacology - 9E (2015)

General Pharmacology
140. Phamacogenetics is associated with: (PGI Dec. 2005)
(a) Variability of enzyme action
(b) Environmental influence
(c) Individual variability in oral absorption
(d) Different mechanism of actions in different
individuals
(e) Different DRC in different individuals
141. Drugs causing SLE are: (PGI June, 2005)
(a) INH
(b) Hydralazine
(c) Procainamide
(d) Ranitidine
(e) Phenytoin
142. Which of the following terms best describes the
antagonism of leukotrienes’ bronchoconstrictor effect
(mediated at the leukotriene receptors) by terbutaline
(acting at the adrenoceptors) in a patient with asthma?
(a) Pharmacologic antagonist
(b) Partial agonist
(c) Physiologic antagonist
(d) Chemical antagonist
143. Which of the following terms best describes a drug
that blocks the action of adrenaline at its receptors by
occupying those receptors without activating them?
(a) Pharmacologic antagonist
(b) Non competitive antagonist
(c) Physiologic antagonist
(d) Chemical antagonist
144. Which of the following most accurately describes the
transmembrane signaling process involved in the
steroid hormone action?
(a) Action on a membrane spanning tyrosine kinase
(b) Action of a G protein, which activates or inhibits
adenylyl cyclase
(c) Diffusion across the membrane and binding to an
intracellular receptor
(d) Opening of transmembrane ion channels
145. Which of the following is most likely due to a
pharmacogenetic condition?
(a) Hypoglycemia by insulin
(b) Tachycardia by albuterol
(c) Metoclopramide induced muscle dystonia
(d) Primaquine induced hemolytic anemia
146. Dose response curves of salbutamol for broncho dilation
and tachycardia are widely separated on the dose axis.
This information suggests that salbutamol is:
(a) Highly potent cardiac stimulant
(b) Highly efficacious bronchodilator
(c) Highly toxic drug
(d) Highly selective drug
147. Fastest acting receptor/transduction mechanism is:
(a) Adenylyl cyclase – cyclic AMP pathway
(b) Phospholipase C-IP3: DAG pathway
(c) Intrinsic ion channel operation
(d) Nuclear receptors
148. Which of the following is an inotropic receptor?
(a) Muscarinic cholinergic receptor
(b) Nicotinic cholinergic receptor
(c) Glucocorticoid receptor
(d) Insulin receptor
149. A partial agonist has:
(a) High affinity but low intrinsic activity
(b) High affinity but no intrinsic activity
(c) Low affinity but high intrinsic activity
(d) Low affinity and low intrinsic activity
150. Which of the following drugs act through heptahelical
(serpentine) receptors?
(a) Insulin
(b) Estrogen
(c) Local anaesthetics
(d) Salbutamol
151. Which of the following does not act as second
messenger?
(a) Cyclic AMP
(b) Inositol trisphosphate
(c) Diacylglycerol
(d) G proteins
152. ‘Drug efficacy’ refers to:
(a) Effectiveness of drug in life threatening conditions
(b) The maximal intensity of response that can be produced
by the drug
(c) The dose of the drug needed to produce half maximal
effect
(d) The minimum dose of the drug needed to produce
toxic effect
153. A 56 yr old man, Surender with heart failure is to be
treated with a diuretic drug. Drugs A and B have same
mechanism of action. Drug A in dose of 50 mg produces
the same magnitude of diuresis as 500 mg of drug B.
This suggests that:
(a) Drug B is less efficacious than drug A
(b) Drug A is more potent than drug B
(c) Drug A is a safer drug than drug B
(d) Drug A will have shorter duration of action than
drug
154. Which of the following has cytoplasmic receptor:
(a) Epinephrine (DPG 2004)
(b) Insulin
(c) FSH
(d) Cortisol
155. Which of the following is true for receptor action of a
drug: (MPPG 2002)
(a) An antagonist has both intrinsic activity and affinity
for receptor
(b) An antagonist has affinity but no intrinsic activity for
receptor
(c) A partial antagonist has no intrinsic activity or
affinity for receptor
(d) Intrinsic activity and affinity are not important for
drug action
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General Pharmacology
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