Review of Pharmacology - 9E (2015)

General Pharmacology
(a) 50 mg/hour
(b) 30 mg/hr
(c) 25 mg/hr
(d) 100 mg/hr.
107. First order kinetics is characterized by:
(a) Dose dependent elimination
(DPG-2008)
(b) Decreasing clearance as plasma concentration
(c)
increases
Increasing rate of elimination as plasma concentration
increases
(d) No relationship between rate of elimination and
plasma concentration
108. Elimination after 4 half lives in first order kinetic is:
(a) 84% (DPG 2005, MH 2005)
(b) 93%
(c) 80.5%
(d) 75%
109. Zero order kinetics is followed by all of the following
drugs EXCEPT: (DPG 2005)
(a) Phenytoin
(b) Barbiturates
(c) Alcohol
(d) Theophylline
110. At toxic doses, zero order kinetics is seen in:
(a) Penicillin (DPG 2003)
(b) Phenytoin
(c) Valproate
(d) Carbamazepine
111. Amount of drug left after four plasma half-lives is:
(a) 6.25% (DPG 2003)
(b) 12.5%
(c) 25%
(d) 50%
112. Inter dose interval depends on: (DPG 2001, MPPG 2002)
(a) Half life of drug
(b) Dose of drug
(c) Age of patient
(d) Bioavailability of drug
tahir99 - UnitedVRG
113. Time required to reach the steady state after a dosage
regimen depends on: (MPPG 2003)
(a) Route of administration
(b) Half life of a drug
(c) Dosage interval
(d) Dose of drug
114. Zero order kinetic is shown by all EXCEPT:
(a) High dose salicylates (Karnataka 2002, MPPG 2001)
(b) Phenytoin
(c) Ethanol
(d) Methotrexate
115. The elimination of alcohol follows: (DNB 2004)
(a) Zero order kinetics
(b) 1st order kinetics
(c) 2nd orders kinetics
(d) 3rd orders kinetics
116. The clearance of drug means: (DNB 2005, 2002)
(a) Volume of plasma which is cleared of drug in unit of
time
(b) Amount of drug excreted in urine
(c) Amount of drug metabolized in unit of time
(d) All of the above
117. Zero order kinetics occur in following drug with high
dose: (DNB 2007, 2003, 2006)
(a) Phenytoin and Theophylline
(b) Digoxin and Propranol
(c) Amiloride and Probenecid
(d) Lithium and Theophylline
118. Zero order kinetics means: (MH 2006)
(a) A constant amount of drug is eliminated per unit time
(b) A constant fraction of the drug in the body is
eliminated per unit time
(c) The fraction of the administered dose that reaches
the systemic circulation
(d) The effect that can be increased by giving a second
agent that boosts the effect ot the liver’s enzyme
system
119. About first order kinetics true statement is: (Bihar 2005)
(a) Clearance remains constant
(b) Fixed amount of the drug is eliminated
(c) Half life increase with dose
(d) Decreased clearance with increasing dose
Pharmacodynamics and pharmacogenetics
120. All of the following can cause SLE-like syndrome
except: (AIIMS May 2013,2012)
(a) Isoniazid
(b) Penicillin
(c) Hydralazine
(d) Sulphonamide
121. The neurotransmitters; nor-adrenaline, adrenaline and
dopamine act through which of the following receptors?
(AIIMS Nov 2011)
(a) Single pass transmembrane receptors
(b) Four pass transmembrane receptors
(c) Seven pass transmembrane receptors
(d) Ligand gated receptors
122. If there is a Gs alpha subunit gain-of-function mutation,
this results in: (AI 2011)
(a) Decreased cAMP
(b) Decreased IP 3
(c) Increased GTPase activity
(d) Increased cAMP
123. Which one of the following statements best describes the
mechanism of action of insulin on target cells?
(Delhi PG 2011)
(a) Insulin binds to cytoplasmic receptor molecule and
is transferred as a hormone receptor complex to the
nucleus where it acts to modulate gene expression.
General Pharmacology
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