Review of Pharmacology - 9E (2015)

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Review of Pharmacology Endocrinology 266 • Infantile spasms • Hypothyroidism • Myxedema coma • Hyperthyroidism Condition Drug of Choice ACTH Levo-thyroxine Levo-thyroxine Drug Carbimazole or methimazole – In lactation Propylthiouracil – In 1st trimester of pregnancy Prophylthiouracil – In 2nd and 3rd trimester of pregnancy Carbimazole or methimazole – Graves' opthalmopathy Methylprednisolone • Thyroid storm • Diabetes mellitus Type 1 (IDDM) Type 2 (NIDDM) Propanolol (life saving)+ Iodides Insulin Metformin – In obese Metformin – Uncontrolled Insulin – Pregnancy Insulin – To tide over stress Insulin • Diabetic ketoacidosis • Post prandial hyperglycemia • Acute hyperkalemia • Beta blocker poisoning • Hypoglycemia • Adrenal insufficiency Insulin (Regular) Nateglinide Calcium gluconate Glucagon Glucose (oral or i.v.) – Acute Hydrocortisone – Chronic (Addison's disease) Hydrocortisone • Erectile dysfunction • Contraceptive Sildenafil – Newly married Combined oral contraceptives – In lactation Mini pills – Emergency contraceptive Levonorgestrel • Anovulatory infertility • Osteoporosis Clomiphene – Post menopausal Alendronate – Steroid-induced Alendronate – In women with risk factors for breast cancer • Hypercalcemia of malignancy • Paget's disease of bone • Tetany • Induction of labour • Post partum hemorrhage • Acromegaly • Esophageal varices Raloxifene Bisphosphonates Bisphosphonates Calcium Oxytocin Oxytocin Cabergoline Terlipressin (if not available, octreotide) Contd... https://kat.cr/user/Blink99/
Endocrinology Contd... • Hyperprolactinemia Cabergoline • Androgenital alopecia Finasteride • Dysfunctional uterine bleeding – Light bleeding Medroxyprogesterone acetate – Heavy bleeding Combined oral contraceptives – Intractable bleeding Leuprolide • Endometriosis Combined oral contraceptives • Ectopic pregnancy Methotrexate General Endocrinology Pharmacology 267 https://kat.cr/user/Blink99/
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Review of Pharmacology Ninth Editio
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Dedicated to My parents, wife Prave
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Preface to the Ninth Edition We wan
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Acknowledgments When emotions are p
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References • Harrison’s Princip
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Contents 1. History of Pharmacology
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CHAPTER 1 History of pharmacology S
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CHAPTER 2 General Pharmacology Phar
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General Pharmacology Note: It is si
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General Pharmacology Drug metaboliz
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General Pharmacology Order of kinet
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General Pharmacology Therapeutic Dr
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General Pharmacology Fig. 2.4: G-pr
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General Pharmacology sigmoid shaped
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General Pharmacology Phase 1: Here,
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General Pharmacology 5. Essential m
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General Pharmacology (b) Bioavailab
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General Pharmacology (c) Are highly
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General Pharmacology (c) Strong aci
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General Pharmacology (a) 50 mg/hour
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General Pharmacology 140. Phamacoge
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General Pharmacology (c) Piroxicam
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206. Which of the following drugs s
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General Pharmacology 29. In which t
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General Pharmacology Explanations 1
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General Pharmacology • Other fact
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General Pharmacology -- Suppose, 10
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General Pharmacology 77. Ans. (a) W
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= 40 L × 4 mg/L = 160 mg Clearance
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General Pharmacology 126. Ans. (c)
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General Pharmacology 154. Ans. (d)
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General Pharmacology Intolerance is
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General Pharmacology 6. Ans. (b) b
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CHAPTER 3 Autonomic Nervous System
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Autonomic Nervous System Functions
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Autonomic Nervous System • Carbac
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Autonomic Nervous System used for g
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Autonomic Nervous System -- Central
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Autonomic Nervous System • Theref
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Autonomic Nervous System • Eye: S
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Autonomic Nervous System • Dopami
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Autonomic Nervous System • Phenox
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Autonomic Nervous System Lipid Inso
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Autonomic Nervous System Drug of Ch
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Multiple Choice Questions Autonomic
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Autonomic Nervous System (c) Organo
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(c) Physostigmime (d) Hyoscine hydr
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Autonomic Nervous System (c) Tropic
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132. A drug that blocks the uptake
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165. Clonidine is used for: (Kolkat
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as an effective substitute which do
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Autonomic Nervous System 13. Which
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Autonomic Nervous System (c) Increa
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Autonomic Nervous System 9. Ans. (a
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Autonomic Nervous System 39. Ans. (
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Autonomic Nervous System - Temazepa
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Autonomic Nervous System 103. Ans.
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Autonomic Nervous System have no ef
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Autonomic Nervous System 23. Ans. (
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CHAPTER 4 Autacoids These are the s
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Autacoids All second generation ant
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Autacoids v v v v v Calcium channel
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Autacoids nary bypass. It can also
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Autacoids to presence of sulfur con
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Autacoids Rheumatoid Arthritis Rheu
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Autacoids It is a monoclonal antibo
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Autacoids Drug of choice Condition
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15. Anti-vertigo drug which modulat
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49. Sumatriptan is: (DPG 1999, TN 2
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81. All of the following effects ar
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114. Which prostaglandin helps in c
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Autacoids 148. Which of the followi
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Autacoids 30. A 15 year old boy was
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Autacoids 16. Ans. (b) Dangerous ve
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Autacoids 56. Ans. (c) Cyclooxygena
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Autacoids 85. Ans. (b) Aspirin supp
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Autacoids 125. Ans. (b) Indomethaci
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Autacoids 13. Ans. (a) Naproxen (Re
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CHAPTER 5 Cardiovascular System CON
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Cardiovascular System In atrial fib
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Cardiovascular System Treatment of
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Cardiovascular System should be use
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Cardiovascular System tive α 1 blo
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Cardiovascular System nifedipine an
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Cardiovascular System Treatment of
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Cardiovascular System ANGINA PECTOR
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Cardiovascular System BETA BLOCKERS
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Cardiovascular System The action po
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Cardiovascular System depolarized c
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Cardiovascular System • Digoxin i
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Cardiovascular System Contd... •
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Cardiovascular System DRUG OF CHOIC
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15. Digoxin toxicity is aggravated
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(c) Treat digoxin toxicity (d) Rapi
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(c) Decreases sodium and increases
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Cardiovascular System 113. All of t
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146. Which of the following drugs i
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Cardiovascular System 180. Characte
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213. In a patient with hypertriglyc
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247. ACE inhibitors cause: (PGI Dec
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Cardiovascular System 16. Dialysis
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Cardiovascular System 53. Which of
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• Nesiritide is a recombinant BNP
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Cardiovascular System 43. Ans. (d)
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Cardiovascular System 81. Ans. (a)
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Cardiovascular System -- Hypertensi
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Cardiovascular System Cyanide has v
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Cardiovascular System 13. Ans (b) P
Page 227 and 228: CHAPTER 6 Kidney Diuretics Diuretic
Page 229 and 230: Kidney Uses Main use of loop diuret
Page 231 and 232: Kidney • Amiloride is more potent
Page 233 and 234: Kidney Amiloride It is the agent of
Page 235 and 236: Kidney Multiple Choice Questions di
Page 237 and 238: 30. Which of the following statemen
Page 239 and 240: 66. Advantage of desmopressin over
Page 241 and 242: Kidney Explanations 1. Ans. (b) Hyp
Page 243 and 244: 16. Ans. (b) Bumetanide (Ref: KDT 6
Page 245 and 246: Kidney 55. Ans (d) V 4 : Central Ne
Page 247 and 248: CHAPTER 7 Endocrinology Hormones ar
Page 249 and 250: Endocrinology Prolactin It causes g
Page 251 and 252: Endocrinology • In the liver and
Page 253 and 254: Endocrinology I 131 can be used for
Page 255 and 256: Endocrinology Drug interactions •
Page 257 and 258: Endocrinology Lactic acidosis (more
Page 259 and 260: Endocrinology 3. amylin analogs Pra
Page 261 and 262: Endocrinology Important Points Maxi
Page 263 and 264: Endocrinology • Steroids with sel
Page 265 and 266: Endocrinology • Vitamin D 2 is er
Page 267 and 268: Endocrinology Denosumab Osteoclasts
Page 269 and 270: Endocrinology • SERMs are targete
Page 271 and 272: Endocrinology Contd... • Uliprist
Page 273 and 274: Endocrinology only pills. Chances o
Page 275 and 276: Endocrinology Pharmacokinetics Test
Page 277: Endocrinology Ergot Derivatives Erg
Page 281 and 282: completion of therapy, the patient
Page 283 and 284: (c) Glucose (d) Starch 47. True abo
Page 285 and 286: (c) Na + exit/K + entry (d) K + ent
Page 287 and 288: Endocrinology 113. Which of the fol
Page 289 and 290: 147. Bisphosphonates act by: (AI 20
Page 291 and 292: 180. Women receiving estrogen thera
Page 293 and 294: (c) Clomiphene (d) Mifepristone (RU
Page 295 and 296: 246. Mechanism of Calcitriol is: (R
Page 297 and 298: Endocrinology 32. Drug used to cont
Page 299 and 300: (b) Glimepiride (c) Repaglinide (d)
Page 301 and 302: Endocrinology Explanations 1. Ans.
Page 303 and 304: Endocrinology 24. Ans. (c) Propylth
Page 305 and 306: Endocrinology • When this drug is
Page 307 and 308: Endocrinology Hypoglycemia is cause
Page 309 and 310: Endocrinology Drugs causing Addison
Page 311 and 312: Endocrinology Raloxifene is a selec
Page 313 and 314: Endocrinology • Enzyme inducers l
Page 315 and 316: Endocrinology 197. Ans. (b) Blocks
Page 317 and 318: Endocrinology A spider angioma (als
Page 319 and 320: Endocrinology 4. Ans (c) Glaucoma (
Page 321 and 322: Endocrinology 70. Ans. (c) Mifepris
Page 323 and 324: NOTES _____________________________
Page 325 and 326: CHAPTER 8 Central Nervous System Se
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Central Nervous System • Abnormal
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Central Nervous System useful in AD
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Central Nervous System Wilson’s D
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Central Nervous System Important Dr
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Central Nervous System • Lamotrig
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Central Nervous System play a role
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Central Nervous System According to
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Central Nervous System bulimia, pre
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Central Nervous System Anti Manic D
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Central Nervous System dependence,
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Central Nervous System increase hea
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Central Nervous System Actions •
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Central Nervous System Contd... •
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(c) Alkalization of the urine will
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Central Nervous System (c) Ketamine
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79. Drug of choice for myoclonic ep
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(c) Phenytoin (d) Valproic acid 112
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146. Which of the following antipsy
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(c) Regular measurements of blood c
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210. A patient Rajnish having depre
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242. Drug useful in malignant hyper
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279. Preferred drug for alcohol wit
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314. Morphine can administered by a
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(c) Analgesia (d) Mydriasis 348. Di
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17. Antiparkinson drug known to cau
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53. Which drug is the most useful i
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Central Nervous System 15. Ans. (c)
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Central Nervous System 39. Ans. (b)
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67. Ans. (a) Phenytoin (Ref: Katzun
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97. Ans. (a) Hepatitis (Ref: KDT 6/
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Central Nervous System 145. Ans (c)
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Central Nervous System 159. Ans. (d
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Central Nervous System 187. Ans. (b
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Central Nervous System 212. Ans. (a
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Central Nervous System 258. Ans. (a
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Central Nervous System 303. Ans. (c
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Central Nervous System 326. Ans. (c
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Central Nervous System 60. Ans. (a)
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CHAPTER 9 Anaesthesia Local Anaesth
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Anaesthesia trigeminal nerve, cervi
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Anaesthesia Centrally Acting Muscle
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Anaesthesia • These drugs release
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Anaesthesia Anaesthetic MAC (% atm)
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Anaesthesia Methemoglobinemia and l
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Anaesthesia Chloroform • It is a
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Anaesthesia Contd... • It does no
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Anaesthesia Anaesthetic agents of c
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Anaesthesia Multiple Choice Questio
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33. Post dural (Spinal) puncture he
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(b) Dantrolene (c) Succinylcholine
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103. Which of the following drugs a
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Anaesthesia 138. Thiopental sodium
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Anaesthesia Explanations 1. Ans (c)
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Anaesthesia 20. Ans. (d) Seizures a
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Anaesthesia 49. Ans. (b) Meprobamat
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Anaesthesia • The patient underwe
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Anaesthesia 91. Ans. (b) Sevofluran
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Anaesthesia • In pheochromocytoma
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CHAPTER 10 Hematology HAEMATINICS T
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Hematology • Deficiency of folic
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Hematology • Main drugs acting as
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Hematology 1. Oral Anticoagulants
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Hematology • Bioavailability of u
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Hematology • Rodenticides contain
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Hematology Condition • Anemia Dru
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(c) Erythropoietin (d) Filgrastim (
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Hematology 46. Tirofiban is a: (RJ
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80. The anticoagulant of choice in
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6. Mechanism of action of clopidogr
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Hematology Explanations 1. Ans. (c)
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Hematology 17. Ans. (d) Oprelvekin
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Hematology 51. Ans. (a) Dabigatran:
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Hematology 71. Ans. (c) Warfarin (R
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Hematology 106. Ans. (c) Streptokin
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CHAPTER 11 Respiratory System Cough
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Respiratory System fast acting also
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Respiratory System LT receptor anta
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Respiratory System Condition • Br
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17. The most prominent and dose rel
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Respiratory System 52. In theophyll
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Respiratory System Explanations 1.
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Respiratory System • Inhalational
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CHAPTER 12 Gastrointestinal Tract P
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Gastrointestinal Tract Contd... --
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Gastrointestinal Tract Anti Emetic
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Gastrointestinal Tract Domperidone
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Gastrointestinal Tract Oral Rehydra
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Gastrointestinal Tract Condition
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(c) Misoprostol (d) Omeprazole 15.
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49. The most effective antiemetic f
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Gastrointestinal Tract recent Quest
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Gastrointestinal Tract Explanations
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Gastrointestinal Tract 30. Ans. (b)
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Gastrointestinal Tract 1. EarlyPhas
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Gastrointestinal Tract 17. Ans. (c)
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CHAPTER 13 Chemotherapy A: General
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Chemotherapy A: General Considerati
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contd... Drugs Binds to Mechanism o
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Contd... Chemotherapy A: General Co
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Clinical Uses Chemotherapy A: Gener
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Important Points About Antimicrobia
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128. Ans. (b) Trovafloxacin (Goodma
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CHAPTER 14 Chemotherapy B: Antimicr
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Chemotherapy B: Antimicrobials for
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Clofazimine It is a dye with lepros
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Foscarnet It is not an antimetaboli
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Human Immunodeficiency Virus (HIV)
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16. Bactericidal drugs in ATT are:
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50. Ethambutol should be used very
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120. Regarding ritonavir use in AID
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ACTs). All of the following combina
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ecent Questions asked by National B
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Explanations Chemotherapy B: Antimi
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25. Ans. (b) Ethionamide (Ref: KDT
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CHAPTER 15 Chemotherapy C: Antineop
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Chemotherapy C: Antineoplastic Drug
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4-5 years). Another distinguishing
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GnRH Antagonists Cetrorelix, ganire
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This drug was used in 1960s as a se
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Multiple Choice Questions Chemother
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37. Which of the following statemen
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CHAPTER 16 Immunomodulators IMMUNOS
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Immunomodulators 9. Antibodies Poly
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Immunomodulators Examples of each t
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Immunomodulators Clinical Diagnosis
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(b) Podophylline (c) Interferon (d)
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(c) Cytarabine (d) Cycloserine 51.
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Immunomodulators Explanations 1. An
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Immunomodulators 14. Ans. (a) Syste
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Immunomodulators 33. Ans. (a) Gluco
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CHAPTER 17 Other Topics and Adverse
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Other Topics and Adverse Effects Co
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17. A 2 years old child without fev
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54. Isotretinoin is: (PGI June, 200
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Other Topics and Adverse Effects (c
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Other Topics and Adverse Effects
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Other Topics and Adverse Effects
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Other Topics and Adverse Effects 39
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Other Topics and Adverse Effects 55
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Other Topics and Adverse Effects Dr
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CHAPTER 18 Drugs of Choice Drug of
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Drugs of Choice Contd... Hypertensi
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Contd... VRSA LINEZOLID/STREPTOGRAM
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CHAPTER 19 New Drugs 1. Abatacept:
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New Drugs 52. Canakinumab: A human
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New Drugs 100. Ecallantide: A plasm
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New Drugs 153. Laronidase: Recombin
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New Drugs 204. Peginesatide: A pept
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New Drugs been approved for the tre
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New Drugs and B lymphocytes after e
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New Drugs prevents nausea and vomit
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CHAPTER 20 Recent Topics TRICYCLIC
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Recent Topics 2. Drugs 5-HT 2 recep
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Recent Topics Arginine NOS NO + Cit
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Recent Topics Contd... Drug Tetracy
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Recent Topics -- If the patient has
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CHAPTER 21 Latest Papers AIIMS Nove
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Latest Papers explanations 1. Ans.
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• Clindamycin and erythromycin ar
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Latest Papers AIIMS May 2014 1. Whi
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Latest Papers explanations 1. Ans.
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13. Ans. a. Hypokalemia (Ref: Harri
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NOTES _____________________________
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Image Based Questions https://kat.c
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Image Based Questions 1. The result
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5. A new antiarrhythmic drug is fou
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10. Amarnath, a 58 year old busines
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14. A 72-year-old male, Hemraj was
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(rapid vs slow induction of anesthe
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