Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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Autonomic Nervous System<br />

80<br />

<strong>Review</strong> <strong>of</strong> <strong>Pharmacology</strong><br />

(c) Belladonna<br />

(d) Barbiturates<br />

47. Drug <strong>of</strong> choice in treatment <strong>of</strong> myasthenia gravis is:<br />

(a) d-Tubocurarine (MPPG 2002)<br />

(b) Hexamethonium<br />

(c) Neostigmine<br />

(d) Gallamine<br />

48. Which <strong>of</strong> the following does not cross the blood brain<br />

barrier? (UP 2005)<br />

(a) Pralidoxime<br />

(b) Obidoxime<br />

(c) Diacetyl-monoxime<br />

(d) Physostigmine<br />

49. Anti-cholinesterases are ineffective against: (UP 2005)<br />

(a) Belladona poisoning<br />

(b) Carbamate poisoning<br />

(c) Postoperative ileus<br />

(d) Cobra bite<br />

50. Acetylcholine is not used commercially because:<br />

(a) Long duration <strong>of</strong> action (UP 2006)<br />

(b) Costly<br />

(c) Rapidly destroyed in the body<br />

(d) Crosses blood brain barrier<br />

51. Which one <strong>of</strong> the following acts commonly both on<br />

parasympathetic and sympathetic division?<br />

(AP 1986) (JIPMER 1986) (TN 1989) (TN 2003)<br />

(a) Atropine<br />

(b) Pilocarpine<br />

(c) Acetylcholine<br />

(d) Adrenaline<br />

52. The short acting anticholinesterase drug is: (TN 2004)<br />

(a) Edrophonium<br />

(b) Demecarium<br />

(c) Dyflos<br />

(d) Ectothiophate<br />

53. Anticholineesterase with effect on CNS is: (TN 2005)<br />

(a) Neostigmine<br />

(b) Pyridostigmine<br />

(c) Physostigmine<br />

(d) Edrophonium<br />

54. Which <strong>of</strong> the following anticholinesterase is derived<br />

from natural source? (TN 2006)<br />

(a) Physostigmine<br />

(b) Neostigmine<br />

(c) Pyridostigmine<br />

(d) Tacrine<br />

55. The a 2<br />

agonist used in glaucoma is: (TN 2008)<br />

(a) Guanacare<br />

(b) Guanabenz<br />

(c) Brimonidine<br />

(d) Tizanidine<br />

56. Blood brain barrier is crossed by: (RJ 2001)<br />

(a) Physostigmine<br />

(b) Neostigmine<br />

(c) Acarbose<br />

(d) All<br />

57. Which antiglaucoma drug can be used in an asthmatic<br />

patient? (RJ 2005)<br />

(a) Timolol<br />

(b) Betaxolol<br />

(c) Propanolol<br />

(d) All<br />

58. Cholinesterase activators are useful for treatment <strong>of</strong><br />

which poisoning? (MH 2000, 2007)<br />

(a) Paraquat<br />

(b) Parathion<br />

(c) Carbamates<br />

(d) Organochlorocompounds<br />

59. Neostigmine used in treatment <strong>of</strong> myasthenia gravis<br />

acts by: (MH 2002)<br />

(a) Increasing the number <strong>of</strong> receptors for acetylcholine<br />

(b) Increasing synthesis <strong>of</strong> acetylcholine<br />

(c) Decreasing breakdown <strong>of</strong> acetylcholine<br />

(d) Increasing actylcholine degradation<br />

60. Which <strong>of</strong> the following drug binds only with the<br />

anionic site <strong>of</strong> cholinesterase? (MH 2008)<br />

(a) Physostigmine<br />

(b) Neostigmine<br />

(c) Edrophonium<br />

(d) Pyridostigmine<br />

61. Which among the following is contraindicated in a<br />

myasthenic patient? (Jharkhand 2006)<br />

(a) Aminoglycosides<br />

(b) Sulphonamides<br />

(c) Penicillin<br />

(d) All<br />

62. A patient requires mild cholinomimetic stimulation<br />

following surgery. Physostigmine and bethanechol<br />

in small doses have significantly different effects on<br />

which <strong>of</strong> the following? (Karnataka 2005)<br />

(a) Gastric secretion<br />

(b) Neuromuscular junction<br />

(c) Sweat glands<br />

(d) Ureteral tone<br />

63. In oral poisoning with carbamate insecticides ...............<br />

may be hazardous: (Karnataka 2001)<br />

(a) Pralidoxime<br />

(b) Atropine<br />

(c) Magnesium sulfate purgative<br />

(d) Gastric lavage with activated charcoal<br />

parasympatholytics<br />

64. Which <strong>of</strong> the following drugs does not cross blood<br />

placental barrier?<br />

(a) Atropine<br />

(b) Glycopyrolate<br />

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