Review of Pharmacology - 9E (2015)

Review of Pharmacology
Multiple Choice Questions
Gastrointestinal Tract
peptic ulcer disease
1. Despite their short half-lives (2 hrs), proton pump
inhibitors (PPIs) cause a prolonged suppression of acid
secretion (up to 48 h) because: (AIIMS May 2012)
(a) They are prodrugs and undergo activation gradually
(b) They exit from the plasma and enter acid secretory
canaliculi and stay there, blocking the secretion of
acid for a long time
(c) They irreversibly inhibit the proton pump molecule
and hence, acid secretion requires synthesis of new
proton pumps
(d) They are available as enteric coated capsules, from
which drug is gradually released
2. Which of the following proton pump inhibitor has
enzyme inhibitory activity? (AI 2010)
(a) Rabeprazole
(b) Lansoprazole
(c) Pantoprazole
(d) Omeprazole
3. Drug not used in H. pylori is: (AIIMS May 2008)
(a) Metronidazole (AIIMS Nov., 2006)
(b) Omeprazole
(c) Mosapride
(d) Amoxicillin
4. Which of the following drugs is not used for H. pylori
treatment? (AI 2007)
(a) Oxytetracycline
(b) Bismuth compounds
(c) Amoxicillin
(d) Omeprazole
5. Which of the following agents is beneficial in NSAID
induced gastric ulcer? (AI 2007)
(a) PGE 1
agonist
(b) PGE 2
agonist
(c) PGD 2
agonist
(d) PGF 2α
agonist
6. A patient of peptic ulcer was prescribed ranitidine
and sucralfate in the morning hours. Why is this
combination incorrect? (AI 2004)
(a) Ranitidine combines with sucralfate and prevents its
action
(b) Combination of these two drugs produces serious
side effects like agranulocytosis
(c) Ranitidine increases the gastric pH so sucralfate is
not able to act.
(d) Sucralfate inhibits the absorption of ranitidine
7. Proton pump inhibitors are most effective when they
are given: (AI 2002)
(a) After meals
(b) Shortly before meals
(c) Along with H 2
blockers
(d) During prolonged fasting periods
8. A patient is taking famotidine, sucralfate and antacid
tablets. This treatment is irrational because: (AI 2000)
(a) Sucralfate decreases the absorption of famotidine
(b) Sucralfate increases the toxicity of famotidine
(c) Sucralfate decreases the absorption of antacids
(d) Sucralfate polymerizes only when gastric pH is less
than 4
9. Gynaecomastia can occur as a side effect of:
(a) Bromocriptine
(b) Cimetidine
(c) Famotidine
(d) Levodopa
10. Choose the correct statement about H 2
receptor
blockers:
(a) They are the most efficacious drugs in inhibiting gastric
acid secretion
(b) They cause faster healing of duodenal ulcers
(c) They prevent stress ulcers in the stomach
(d) They afford the most prompt relief of ulcer pain
11. Ranitidine differs from cimetidine in the following
respect:
(a) It is less potent
(b) It is shorter acting
(c) It does not have anti-androgenic action
(d) It produces more CNS side effects
12. The most efficacious drug for inhibiting round the
clock gastric acid output is:
(a) Omeprazole
(b) Cimetidine
(c) Pirenzepine
(d) Misoprostol
13. In peptic ulcer, antacids are now primarily used for:
(a) Prompt pain relief
(b) Ulcer healing
(c) Preventing ulcer relapse
(d) Control of bleeding from the ulcer
14. The following anti ulcer drug DOES NOT act by
reducing the secretion of or neutralizing gastric acid:
(a) Megaldrate
(b) Sucralfate
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