Review of Pharmacology - 9E (2015)

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Review of Pharmacology 4. Drugs Effecive Against Mrsa • Vancomycin • Teicoplanin • Oritavancin • Telavancin • Dalbavancin • Streptogramins • Linezolide • Daptomycin • Cotrimoxazole • Rifampicin • Tetracyclines Note: No β-lactam is effective against MRSA except 5th generation cephalosporins. 5. Antimicrobials of Choice for Prophylaxis (Ref. Katzung 12th/912) Chemotherapy A: General Considerations and Non-specific... Cholera: Tetracycline Rheumatic fever: Benzathine penicillin Tuberculosis: Isoniazid alone or with rifampicin Meningococcal meningitis: Rifampicin/Ciprofloxacin/Ceftriaxone Gonorrhoea / Syphilis: Procaine Penicillin Rickettsial infections: Tetracyclines Malaria: Chloroquine/Mefloquine/Doxycycline Influenza A and B Osetamivir Surgical prophylaxis: Cefazolin Anthrax Ciprofloxacin/Doxycycline Diphtheria Penicillin/Erythromycin Endocarditis Amoxycillin/Clindamycin Herpes Simplex Acyclovir Group B streptococcal infection Ampicillin Hemophilus influenza type B Rifampicin Mycobacterium avium complex (MAC) Azithromycin/Clarithromycin/Rifabutin Otitis media Amoxicillin Pertussis Azithromycin Plague Tetracycline Pneumocystis jiroveci Cotrimoxazole/Dapsone/Atovaquone Toxoplasmosis Cotrimoxazole Urinary tract infections Cotrimoxazole 6. Most Important Mechanism of Drug Resistance Beta lactams Inactivating enzyme (beta lactamase) Tetracyclines Efflux pump (decreased concentration in the cell) Chloramphenicol Inactivating enzyme (acetyl transferase) Aminoglycosides Inactivating enzyme Macrolides Decreased permeability or efflux pumps Sulfonamides Form large amount of PABA Decreased activity of folate synthase Fluoroquinolones Altered DNA gyrase with reduced affinity Note: Transfer of resistance against all antibiotics is plasmid mediated except fluoroquinolones (due to chromosomal mutation). 534 https://kat.cr/user/Blink99/
Chemotherapy A: General Consideration and Non-specific Antimicrobial Agents 7. Drugs Of Choice For Suspected or Proved Microbial Pathogens (Ref. CMDT, 2015) Organism Gram-positive cocci Streptococcus Drug of Choice • S. pneumoniae • Penicillin G 1 • Hemolytic, groups A, B, C, G • Penicillin G 1 • S. viridans • Penicillin G 1, 2 Staphylococcus • Non penicillinase producing • Penicillin G 1 • Penicillinase producing • Penicillinase resistant penicillin (cloxa, oxa, naf or dicloxacillin) • Methicillin resistant (MRSA) • Vancomycin • Coagulase negative • Vancomycin Enterococcus • faecalis • Ampiillin 3 • faecium • Vancomycin 3 Gram-positive bacilli • Actinomyces • Penicillin G • Bacillus -- Anthracis • Ciprofloxacin or Doxycycline -- Cereus and others • Penicillin G • Clostridium • Pencillin G • Corynebacterium • Erythromycin 4 • Listeria • Ampicillin 5 Gram-negative cocci • Neisseria -- meningitidis • Penicillin G -- gonorrhae • Ceftriaxone + Azithromycin/Doxycycline • Moraxella • Fluoroquinolones Gram-negative bacilli • Campylobacter • Macrolides • Legionella • Macrolides • Bordetella • Macrolides • Brucella • Doxycyline + Rifampicin • Acinetobacter • Carbapenems • Hemophilus -- Serious infections like meningitis • Ceftriaxone -- Respiratory infections, otitis • Cotrimoxazole -- Ducreyi (chancroid) • Azithromycin • Prevotella • Clindamycin • Bacteroides • Metronidazole • Pseudomonas • Anti-Pseudomonal b-lactam (piperacillin or ceftazidime or cefepime or imipenem) + Gentamicin Chemotherapy A: General Considerations Pharmacology and Non-specific... 535 https://kat.cr/user/Blink99/
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Review of Pharmacology Ninth Editio
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Dedicated to My parents, wife Prave
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Preface to the Ninth Edition We wan
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Acknowledgments When emotions are p
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References • Harrison’s Princip
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Contents 1. History of Pharmacology
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CHAPTER 1 History of pharmacology S
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CHAPTER 2 General Pharmacology Phar
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General Pharmacology Note: It is si
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General Pharmacology Drug metaboliz
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General Pharmacology Order of kinet
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General Pharmacology Therapeutic Dr
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General Pharmacology Fig. 2.4: G-pr
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General Pharmacology sigmoid shaped
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General Pharmacology Phase 1: Here,
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General Pharmacology 5. Essential m
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General Pharmacology (b) Bioavailab
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General Pharmacology (c) Are highly
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General Pharmacology (c) Strong aci
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General Pharmacology (a) 50 mg/hour
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General Pharmacology 140. Phamacoge
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General Pharmacology (c) Piroxicam
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206. Which of the following drugs s
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General Pharmacology 29. In which t
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General Pharmacology Explanations 1
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General Pharmacology • Other fact
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General Pharmacology -- Suppose, 10
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General Pharmacology 77. Ans. (a) W
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= 40 L × 4 mg/L = 160 mg Clearance
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General Pharmacology 126. Ans. (c)
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General Pharmacology 154. Ans. (d)
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General Pharmacology Intolerance is
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General Pharmacology 6. Ans. (b) b
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CHAPTER 3 Autonomic Nervous System
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Autonomic Nervous System Functions
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Autonomic Nervous System • Carbac
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Autonomic Nervous System used for g
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Autonomic Nervous System -- Central
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Autonomic Nervous System • Theref
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Autonomic Nervous System • Eye: S
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Autonomic Nervous System • Dopami
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Autonomic Nervous System • Phenox
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Autonomic Nervous System Lipid Inso
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Autonomic Nervous System Drug of Ch
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Multiple Choice Questions Autonomic
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Autonomic Nervous System (c) Organo
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(c) Physostigmime (d) Hyoscine hydr
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Autonomic Nervous System (c) Tropic
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132. A drug that blocks the uptake
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165. Clonidine is used for: (Kolkat
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as an effective substitute which do
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Autonomic Nervous System 13. Which
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Autonomic Nervous System (c) Increa
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Autonomic Nervous System 9. Ans. (a
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Autonomic Nervous System 39. Ans. (
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Autonomic Nervous System - Temazepa
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Autonomic Nervous System 103. Ans.
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Autonomic Nervous System have no ef
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Autonomic Nervous System 23. Ans. (
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CHAPTER 4 Autacoids These are the s
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Autacoids All second generation ant
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Autacoids v v v v v Calcium channel
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Autacoids nary bypass. It can also
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Autacoids to presence of sulfur con
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Autacoids Rheumatoid Arthritis Rheu
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Autacoids It is a monoclonal antibo
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Autacoids Drug of choice Condition
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15. Anti-vertigo drug which modulat
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49. Sumatriptan is: (DPG 1999, TN 2
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81. All of the following effects ar
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114. Which prostaglandin helps in c
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Autacoids 148. Which of the followi
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Autacoids 30. A 15 year old boy was
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Autacoids 16. Ans. (b) Dangerous ve
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Autacoids 56. Ans. (c) Cyclooxygena
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Autacoids 85. Ans. (b) Aspirin supp
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Autacoids 125. Ans. (b) Indomethaci
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Autacoids 13. Ans. (a) Naproxen (Re
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CHAPTER 5 Cardiovascular System CON
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Cardiovascular System In atrial fib
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Cardiovascular System Treatment of
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Cardiovascular System should be use
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Cardiovascular System tive α 1 blo
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Cardiovascular System nifedipine an
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Cardiovascular System Treatment of
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Cardiovascular System ANGINA PECTOR
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Cardiovascular System BETA BLOCKERS
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Cardiovascular System The action po
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Cardiovascular System depolarized c
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Cardiovascular System • Digoxin i
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Cardiovascular System Contd... •
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Cardiovascular System DRUG OF CHOIC
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15. Digoxin toxicity is aggravated
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(c) Treat digoxin toxicity (d) Rapi
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(c) Decreases sodium and increases
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Cardiovascular System 113. All of t
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146. Which of the following drugs i
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Cardiovascular System 180. Characte
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213. In a patient with hypertriglyc
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247. ACE inhibitors cause: (PGI Dec
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Cardiovascular System 16. Dialysis
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Cardiovascular System 53. Which of
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• Nesiritide is a recombinant BNP
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Cardiovascular System 43. Ans. (d)
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Cardiovascular System 81. Ans. (a)
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Cardiovascular System -- Hypertensi
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Cardiovascular System Cyanide has v
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Cardiovascular System 13. Ans (b) P
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CHAPTER 6 Kidney Diuretics Diuretic
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Kidney Uses Main use of loop diuret
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Kidney • Amiloride is more potent
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Kidney Amiloride It is the agent of
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Kidney Multiple Choice Questions di
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30. Which of the following statemen
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66. Advantage of desmopressin over
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Kidney Explanations 1. Ans. (b) Hyp
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16. Ans. (b) Bumetanide (Ref: KDT 6
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Kidney 55. Ans (d) V 4 : Central Ne
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CHAPTER 7 Endocrinology Hormones ar
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Endocrinology Prolactin It causes g
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Endocrinology • In the liver and
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Endocrinology I 131 can be used for
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Endocrinology Drug interactions •
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Endocrinology Lactic acidosis (more
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Endocrinology 3. amylin analogs Pra
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Endocrinology Important Points Maxi
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Endocrinology • Steroids with sel
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Endocrinology • Vitamin D 2 is er
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Endocrinology Denosumab Osteoclasts
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Endocrinology • SERMs are targete
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Endocrinology Contd... • Uliprist
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Endocrinology only pills. Chances o
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Endocrinology Pharmacokinetics Test
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Endocrinology Ergot Derivatives Erg
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Endocrinology Contd... • Hyperpro
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completion of therapy, the patient
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(c) Glucose (d) Starch 47. True abo
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(c) Na + exit/K + entry (d) K + ent
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Endocrinology 113. Which of the fol
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147. Bisphosphonates act by: (AI 20
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180. Women receiving estrogen thera
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(c) Clomiphene (d) Mifepristone (RU
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246. Mechanism of Calcitriol is: (R
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Endocrinology 32. Drug used to cont
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(b) Glimepiride (c) Repaglinide (d)
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Endocrinology Explanations 1. Ans.
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Endocrinology 24. Ans. (c) Propylth
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Endocrinology • When this drug is
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Endocrinology Hypoglycemia is cause
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Endocrinology Drugs causing Addison
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Endocrinology Raloxifene is a selec
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Endocrinology • Enzyme inducers l
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Endocrinology 197. Ans. (b) Blocks
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Endocrinology A spider angioma (als
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Endocrinology 4. Ans (c) Glaucoma (
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Endocrinology 70. Ans. (c) Mifepris
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NOTES _____________________________
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CHAPTER 8 Central Nervous System Se
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Central Nervous System It is admini
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Central Nervous System • Abnormal
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Central Nervous System useful in AD
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Central Nervous System Wilson’s D
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Central Nervous System Important Dr
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Central Nervous System • Lamotrig
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Central Nervous System play a role
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Central Nervous System According to
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Central Nervous System bulimia, pre
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Central Nervous System Anti Manic D
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Central Nervous System dependence,
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Central Nervous System increase hea
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Central Nervous System Actions •
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Central Nervous System Contd... •
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(c) Alkalization of the urine will
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Central Nervous System (c) Ketamine
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79. Drug of choice for myoclonic ep
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(c) Phenytoin (d) Valproic acid 112
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146. Which of the following antipsy
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(c) Regular measurements of blood c
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210. A patient Rajnish having depre
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242. Drug useful in malignant hyper
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279. Preferred drug for alcohol wit
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314. Morphine can administered by a
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(c) Analgesia (d) Mydriasis 348. Di
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17. Antiparkinson drug known to cau
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53. Which drug is the most useful i
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Central Nervous System 15. Ans. (c)
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Central Nervous System 39. Ans. (b)
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67. Ans. (a) Phenytoin (Ref: Katzun
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97. Ans. (a) Hepatitis (Ref: KDT 6/
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Central Nervous System 145. Ans (c)
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Central Nervous System 159. Ans. (d
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Central Nervous System 187. Ans. (b
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Central Nervous System 212. Ans. (a
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Central Nervous System 258. Ans. (a
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Central Nervous System 303. Ans. (c
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Central Nervous System 326. Ans. (c
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Central Nervous System 60. Ans. (a)
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CHAPTER 9 Anaesthesia Local Anaesth
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Anaesthesia trigeminal nerve, cervi
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Anaesthesia Centrally Acting Muscle
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Anaesthesia • These drugs release
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Anaesthesia Anaesthetic MAC (% atm)
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Anaesthesia Methemoglobinemia and l
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Anaesthesia Chloroform • It is a
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Anaesthesia Contd... • It does no
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Anaesthesia Anaesthetic agents of c
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Anaesthesia Multiple Choice Questio
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33. Post dural (Spinal) puncture he
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(b) Dantrolene (c) Succinylcholine
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103. Which of the following drugs a
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Anaesthesia 138. Thiopental sodium
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Anaesthesia Explanations 1. Ans (c)
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Anaesthesia 20. Ans. (d) Seizures a
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Anaesthesia 49. Ans. (b) Meprobamat
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Anaesthesia • The patient underwe
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Anaesthesia 91. Ans. (b) Sevofluran
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Anaesthesia • In pheochromocytoma
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CHAPTER 10 Hematology HAEMATINICS T
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Hematology • Deficiency of folic
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Hematology • Main drugs acting as
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Hematology 1. Oral Anticoagulants
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Hematology • Bioavailability of u
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Hematology • Rodenticides contain
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Hematology Condition • Anemia Dru
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(c) Erythropoietin (d) Filgrastim (
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Hematology 46. Tirofiban is a: (RJ
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80. The anticoagulant of choice in
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6. Mechanism of action of clopidogr
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Hematology Explanations 1. Ans. (c)
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Hematology 17. Ans. (d) Oprelvekin
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Hematology 51. Ans. (a) Dabigatran:
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Hematology 71. Ans. (c) Warfarin (R
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Hematology 106. Ans. (c) Streptokin
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CHAPTER 11 Respiratory System Cough
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Respiratory System fast acting also
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Respiratory System LT receptor anta
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Respiratory System Condition • Br
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17. The most prominent and dose rel
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Respiratory System 52. In theophyll
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Respiratory System Explanations 1.
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Page 497 and 498: CHAPTER 12 Gastrointestinal Tract P
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Page 501 and 502: Gastrointestinal Tract Anti Emetic
Page 503 and 504: Gastrointestinal Tract Domperidone
Page 505 and 506: Gastrointestinal Tract Oral Rehydra
Page 507 and 508: Gastrointestinal Tract Condition
Page 509 and 510: (c) Misoprostol (d) Omeprazole 15.
Page 511 and 512: 49. The most effective antiemetic f
Page 513 and 514: Gastrointestinal Tract recent Quest
Page 515 and 516: Gastrointestinal Tract Explanations
Page 517 and 518: Gastrointestinal Tract 30. Ans. (b)
Page 519 and 520: Gastrointestinal Tract 1. EarlyPhas
Page 521 and 522: Gastrointestinal Tract 17. Ans. (c)
Page 523 and 524: CHAPTER 13 Chemotherapy A: General
Page 525 and 526: Chemotherapy A: General Considerati
Page 527 and 528: contd... Drugs Binds to Mechanism o
Page 533 and 534: Contd... Chemotherapy A: General Co
Page 537 and 538: Clinical Uses Chemotherapy A: Gener
Page 545: Important Points About Antimicrobia
Page 579 and 580: 128. Ans. (b) Trovafloxacin (Goodma
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Page 593 and 594: Clofazimine It is a dye with lepros
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Foscarnet It is not an antimetaboli
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Human Immunodeficiency Virus (HIV)
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Chemotherapy B: Antimicrobials for
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16. Bactericidal drugs in ATT are:
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50. Ethambutol should be used very
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120. Regarding ritonavir use in AID
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ACTs). All of the following combina
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ecent Questions asked by National B
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Explanations Chemotherapy B: Antimi
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25. Ans. (b) Ethionamide (Ref: KDT
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CHAPTER 15 Chemotherapy C: Antineop
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Chemotherapy C: Antineoplastic Drug
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4-5 years). Another distinguishing
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GnRH Antagonists Cetrorelix, ganire
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This drug was used in 1960s as a se
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Multiple Choice Questions Chemother
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37. Which of the following statemen
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CHAPTER 16 Immunomodulators IMMUNOS
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Immunomodulators 9. Antibodies Poly
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Immunomodulators Examples of each t
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Immunomodulators Clinical Diagnosis
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(b) Podophylline (c) Interferon (d)
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(c) Cytarabine (d) Cycloserine 51.
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Immunomodulators Explanations 1. An
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Immunomodulators 14. Ans. (a) Syste
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Immunomodulators 33. Ans. (a) Gluco
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CHAPTER 17 Other Topics and Adverse
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Other Topics and Adverse Effects Co
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17. A 2 years old child without fev
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54. Isotretinoin is: (PGI June, 200
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Other Topics and Adverse Effects (c
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Other Topics and Adverse Effects
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Other Topics and Adverse Effects
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Other Topics and Adverse Effects 39
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Other Topics and Adverse Effects 55
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Other Topics and Adverse Effects Dr
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CHAPTER 18 Drugs of Choice Drug of
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Drugs of Choice Contd... Hypertensi
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Contd... VRSA LINEZOLID/STREPTOGRAM
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CHAPTER 19 New Drugs 1. Abatacept:
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New Drugs 52. Canakinumab: A human
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New Drugs 100. Ecallantide: A plasm
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New Drugs 153. Laronidase: Recombin
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New Drugs 204. Peginesatide: A pept
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New Drugs been approved for the tre
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New Drugs and B lymphocytes after e
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New Drugs prevents nausea and vomit
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CHAPTER 20 Recent Topics TRICYCLIC
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Recent Topics 2. Drugs 5-HT 2 recep
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Recent Topics Arginine NOS NO + Cit
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Recent Topics Contd... Drug Tetracy
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Recent Topics -- If the patient has
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CHAPTER 21 Latest Papers AIIMS Nove
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Latest Papers explanations 1. Ans.
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• Clindamycin and erythromycin ar
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Latest Papers AIIMS May 2014 1. Whi
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Latest Papers explanations 1. Ans.
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13. Ans. a. Hypokalemia (Ref: Harri
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NOTES _____________________________
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Image Based Questions https://kat.c
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Image Based Questions 1. The result
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5. A new antiarrhythmic drug is fou
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10. Amarnath, a 58 year old busines
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14. A 72-year-old male, Hemraj was
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(rapid vs slow induction of anesthe
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