Review of Pharmacology - 9E (2015)

79. Drug of choice for myoclonic epilepsy in pregnancy is:
(a) Carbamazepine (AI 2000)
(b) Sodium valproate
(c) Phenobarbitone
(d) Phenytoin
80. Regarding Phenytoin, false is: (AIIMS Nov., 2007)
(a) Induces microsomal enzymes
(b) At very low doses, zero order kinetics occurs
(c) Higher the dose, higher is the half life
(d) Highly protein bound
81. Prolonged use of one of the following anticonvulsant
drugs can produce weight loss: (AIIMS May, 2006 )
(a) Gabapentin
(b) Oxcarbazepine
(c) Topiramate
(d) Valproic acid
82. Which of the following antiepileptic agents acts on the
GABAergic system to decrease the uptake of GABA
into neurons and glial cells? (AIIMS Nov, 2005)
(a) Vigabatrin (RJ 2007)
(b) Progabide
(c) Gabapentin
(d) Tiagabine
83. A 30-year old epileptic female, Kamla on phenytoin
therapy, developed weakness and fatigue. Blood
examination revealed Hb = 4.6 gm. MCV = 102 fl and
MCH = 40 pg/dl. What is the most probable diagnosis?
(a) Heart failure (AIIMS Nov, 2003)
(b) Iron deficiency anemia
(c) Phenytoin induced agranulocytosis
(d) Megaloblastic anemia
84. A patient with recent-onset primary generalized
epilepsy develops drug reaction and skin rash due to
phenytoin sodium. The most appropriate course of
action is: (AIIMS May, 2003)
(a) Shift to clonazepam
(b) Restart phenytoin sodium after 2 weeks
(c) Shift to sodium valproate
(d) Shift to ethosuximide
85. Adverse effect of phenytoin include all of the following
EXCEPT: (AIIMS Nov, 2002)
(a) Lymphadenopathy
(b) Ataxia
(c) Hypercalcemia
(d) Hirsutism
86. On chronic treatment with a drug, a patient presents
with gingival hyperplasia and facial hirsutism. The
drug most likely to cause these side effects is:
(a) Phenytoin (AIIMS May, 2002)
(b) Carbamazepine
(c) Valproic acid
(d) Phenobarbitone
Central Nervous System
87. Which of the following is correctly matched:
(a) Gabapentin – GABA transaminase inhibitor
(b) Zonisamide – Ca 2+ channel blocker
(c) Carbamazepine – Na + channel blocker
(d) Lamotrigine – NMDA blocker (PGI Dec. 2007)
(e) Tiagabine – Increases release of GABA
88. Which of the following are the features of phenytoin
toxicity: (PGI June, 2007)
(a) Gum hypertrophy
(b) Acne rosacea
(c) Exacerbation of acne vulgaris
(d) Loss of hair
(e) Nystagmus
89. Mg ++ can be administered in: (PGI June, 2006)
(a) Eclampsia
(b) Cardiac arrhythmia
(c) Seizure
(d) Tetany
(e) Asthma
90. Therapeutic level of phenytoin is: (PGI Dec. 2005)
(a) 0-9 mg/ml
(b) 10-19 mg/ml
(c) 20-29 mg/ml
(d) 30-39 mg/ml
(e) 40+ mg/ml
91. Drugs used in GTCS is/are: (PGI Dec 2005)
(a) Ethosuximide
(b) Sodium-valproate
(c) Lamotrigine
(d) Propofol
92. Side effects of phenytoin are: (PGI Dec. 2004)
(a) Gum hypertrophy
(b) Alopecia
(c) Subungal exostosis
(d) Onycholysis
(e) Acne rosacea
93. Which of the following statements about vigabatrin is
TRUE?
(a) Blocks neuronal reuptake of GABA
(b) Drug of choice in absence seizures
(c) Life threatening skin disorders may occur
(d) Visual disturbances can occur
94. Phenytoin pharmacokinetics is highlighted by which of
the following characteristics?
(a) High first pass metabolism
(b) Nonsaturation kinetics of metabolism
(c) Capacity limited metabolism saturating at higher
therapeutic concentration range
(d) Extrahepatic metabolism
95. High plasma drug concentration of phenytoin can cause
which of the following adverse effects?
(a) Ataxia
(b) Hirsutism
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