Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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(c) Phenytoin<br />

(d) Valproic acid<br />

112. Myoclonus in children is best treated by:<br />

(a) Clonazepam (DPG 2005)<br />

(b) Sodium Valproate<br />

(c) Phenobarbitone<br />

(d) Ethosuccimide<br />

113. DOC for myoclonic seizure is: (DPG 2004<br />

(a) Phenobarbitone Jharkhand 2004)<br />

(b) Ethosuximide<br />

(c) Lamotrigine<br />

(d) Valproic acid<br />

114. All are the side effects <strong>of</strong> prolonged phenytoin therapy<br />

EXCEPT: (DPG 2002)<br />

(a) Osteomalacia<br />

(b) Gynaecomastia<br />

(c) Megaloblastic anemia<br />

(d) Gum hyperplasia<br />

115. Antiepileptic drug that can cause folate deficiency<br />

anemia is: (DPG 1999)<br />

(a) Valproate<br />

(b) Phenytoin<br />

(c) Phenobarbitone<br />

(d) Carbamazepine<br />

116. Which <strong>of</strong> the following antiepileptic drugs acts by<br />

affecting the levels <strong>of</strong> GABA? (DPG 1997)<br />

(a) Sodium valproate<br />

(b) Ethosuximide<br />

(c) Phenytoin sodium<br />

(d) Carbamazepine<br />

117. Which one <strong>of</strong> the following drugs is used to treat status<br />

epilepticus? (MPPG 2007)<br />

(a) Primidone<br />

(b) Carbamazepine<br />

(c) Diazepam<br />

(d) Sodium valporate<br />

118. The antiepileptic drug which does not produce enzyme<br />

induction is: (MPPG 2005)<br />

(a) Phenobarbitone<br />

(b) Sodium valproate<br />

(c) Phenytoin sodium<br />

(d) Carbamazepine<br />

119. Osteomalacia is adverse effect <strong>of</strong>: (UP 2006)<br />

(a) Primidone<br />

(b) Phenytoin<br />

(c) Carbamazepine<br />

(d) Valproic acid<br />

120. Among the following structures which one is not used<br />

in the treatment <strong>of</strong> epilepsy?<br />

(a) Barbiturates (AP 1998) (TN 2000)<br />

(b) Hydantoins<br />

(c) Acetylurea<br />

(d) Atropine<br />

Central Nervous System<br />

121. Gum hypertrophy is an adverse effect <strong>of</strong> the following<br />

drug when used at therapeutic levels: (TN 2003)<br />

(a) Phenobarbitone<br />

(b) Phenytoin<br />

(c) Carbamazepine<br />

(d) Sodium evaporate<br />

122. Drug <strong>of</strong> choice in complex partial seizure is:<br />

(a) Phenytoin (MH 2005, RJ 2004)<br />

(b) Valproate<br />

(c) Carbamazepine<br />

(d) Phenobarbitone<br />

123. Which drug should be avoided in pregnancy?<br />

(a) Phenytoin (RJ 2004)<br />

(b) Insulin<br />

(c) Heparin<br />

(d) All<br />

124. Which <strong>of</strong> the following antiepileptic agent does not act<br />

via Na + channel modulation? (RJ 2008)<br />

(a) Vigabatrin<br />

(b) Phenytoin<br />

(c) Valproate<br />

(d) Lamotrigne<br />

125. Side effects <strong>of</strong> phenytoin are all except: (MH 2002)<br />

(a) Osteomalacia<br />

(b) Maculopapular rash<br />

(c) Sedation<br />

(d) Megaloblastic anaemia<br />

126. Antiepileptics used as analgesics are: (MH 2002)<br />

(a) Carbamazepine and valproate<br />

(b) Phenytoin and valproate<br />

(c) Carbamazepine and phenytoin<br />

(d) Diazepam and Chlorpromazine<br />

127. A patient on anticonvulsant therapy took 20 tablets at<br />

a time following which he developed hyponatremia<br />

and BP <strong>of</strong> 160/100 mm <strong>of</strong> Hg. Which <strong>of</strong> the following<br />

anticonvulsant toxicity is most likely responsible for<br />

this?<br />

(a) Carbamazepine (MH 2007)<br />

(b) Phenytoin sodium<br />

(c) Phenobarbital<br />

(d) Sodium valproate<br />

128. The side effect <strong>of</strong> phenytoin when its plasma<br />

concentration is above therapeutic level is: (Bihar 2003)<br />

(a) Ataxia<br />

(b) Gum hypertrophy<br />

(c) Osteomalacia<br />

(d) Hirsutism<br />

129. Neural tube defect is an adverse effect <strong>of</strong>: (Bihar 2004)<br />

(a) Valproate<br />

(b) Phenytoin<br />

(c) Diazoxide<br />

(d) None<br />

349<br />

General Central Nervous <strong>Pharmacology</strong> System<br />

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