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Review of Pharmacology - 9E (2015)

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Autacoids<br />

30. A 15 year old boy was stung by a bee. He had difficulty<br />

in breathing and facial edema. What is the best<br />

treatment?<br />

(a) IV Adrenaline<br />

(b) SC Adrenaline<br />

(c) IV Antihistamine<br />

(d) IV Hydrocortisone<br />

31. All <strong>of</strong> the following are well known ototoxic drugs<br />

except:<br />

(a) Aspirin<br />

(b) Acetaminophen<br />

(c) Aminoglycosides<br />

(d) Loop diuretics<br />

32. Which one is a contraindication to the use <strong>of</strong> ergot<br />

derivatives:<br />

(a) Migraine<br />

(b) Hyperprolactinemia<br />

(c) Obstructive vascular disease<br />

(d) Postpartum hemorrhage<br />

33. Triptans used in migraine headaches are agonists at<br />

which receptor:<br />

(a) 5HT ID/IB<br />

(b) 5HT 1A<br />

(c) 5HT 3<br />

(d) 5HT 2A<br />

34. Gout is a disorder associated with:<br />

(a) Increase in lactic acid<br />

(b) Increase in uric acid<br />

(c) Increase in hippuric acid<br />

(d) Increase in glutamic acid<br />

35. Which one <strong>of</strong> the following drug and active metabolite<br />

combination is incorrect:<br />

(a) Hydroxyzine-Cetirizine<br />

(b) Terfenadine-Fex<strong>of</strong>enadine<br />

(c) Chlorpromazine-Promethazine<br />

(d) Loratidine-Desloratidine<br />

36. The drug which blocks both H 1<br />

and 5 HT 2<br />

receptor is:<br />

(a) Phenoxybenzamine<br />

(b) Cyproheptadine<br />

(c) Ritanserin<br />

(d) Ondansetron<br />

37. Prostaglandins are synthesized from:<br />

(a) Lignoceric acid<br />

(b) Nervonic acid<br />

(c) Arachidonic acid<br />

(d) Butyric acid<br />

38. Which <strong>of</strong> the following actions are performed by prostacyclin<br />

PGI 2<br />

:<br />

(a) Vasodilation and platelet aggregation<br />

(b) Vasodilation and inhibition <strong>of</strong> platelet aggregation<br />

(c) Vasoconstriction and platelet aggregation<br />

(d) Vasoconstriction and inhibition <strong>of</strong> platelet aggregation<br />

39. All <strong>of</strong> the following are true about prostaglandin E 2<br />

except:<br />

(a) It is the principal prostaglandin synthesized in the<br />

stomach<br />

(b) Its biosynthesis is inhibited by aspirin<br />

(c) It stimulates gastric acid secretion<br />

(d) It causes dilatation <strong>of</strong> submucosa blood vessels<br />

40. Serotonin can be synthesized from:<br />

(a) Tryptophan<br />

(b) Tyrosine<br />

(c) Dopa<br />

(d) Epinephrine<br />

41. Uricosuric drug among these is:<br />

(a) Probenecid<br />

(b) Colchicine<br />

(c) Allopurinol<br />

(d) All <strong>of</strong> these<br />

42. Allopurinol works on the basis <strong>of</strong>:<br />

(a) Decreased excretion <strong>of</strong> uric acid<br />

(b) Decreased metabolism <strong>of</strong> uric acid<br />

(c) Increased excretion <strong>of</strong> uric acid<br />

(d) Decreased synthesis <strong>of</strong> uric acid<br />

43. Latanoprost is used in treatment <strong>of</strong>:<br />

(a) Induction <strong>of</strong> labor<br />

(b) Refraction<br />

(c) Glaucoma<br />

(d) Iridocyclitis<br />

General Autacoids <strong>Pharmacology</strong><br />

137<br />

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