Review of Pharmacology - 9E (2015)

Review of Pharmacology
Multiple Choice Questions
Endocrinology
268
Pituitary and hypothalamus
1. Which of the following is not an adverse effect of
growth hormone therapy? (AIIMS May 2012)
(a) Carpal tunnel syndrome
(b) Hypoglycemia
(c) Intracranial hypertension
(d) Slipped femoral epiphysis
2. Which of the following is used in the treatment of hyperprolactinemia?
(AIIMS May 2012)
(a) Cimetidine
(b) Methysergide
(c) Bromocriptine
(d) Ondansetron
3. A 22 year old female, Neeta presented to you with
complaints of headache and vomiting since 2 months.
She is having amenorrhea but urine pregnancy test
is negative. She also complained of secretion of milk
from the breasts. A provisional diagnosis of hyper
prolactinemia was made and MRI was suggested. MRI
confirmed the presence of a large pituitary adenoma.
Neeta was advised surgery, however, she is not willing
to undergo surgery. Which of the following medications
is most likely to be prescribed? (AI 2011)
(a) Sumatriptan
(b) Bromocrptine
(c) Ergotamine
(d) Allopurinol
4. Octerotide is used in all except: (AIIMS May 2011)
(a) Glucagonoma
(b) Insulinoma
(c) Carcinoid syndrome
(d) Glioma
5. All of the following statements about octreotide are
true EXCEPT: (AI 2007)
(a) It is effective orally
(b) It is used for the treatment of acromegaly
(c) It can be used for the management of secretory
diarrhoea
(d) It can be used in portal hypertension
6. Octreotide is useful in esophageal varices. It is a synthetic
analogue of somatostatin. The true statement
regarding this drug is:
(a) It can be given orally
(b) It is longer acting than somatostatin
(c) Its major adverse effect is secretory diarrhea
(d) All of the above
7. All of the following agents are useful in acromegaly
EXCEPT:
(a) Bromocriptine
(b) Somatostatin
(c) Octreotide
(d) Nafarelin
8. Mechanism of action of bromocriptine is:
(a) Agonism at D 2
receptors
(b) Antagonism at D 2
receptors
(c) Antagonism at D 1
receptors
(d) Antagonism at α receptors
9. Important difference between leuprolide and ganirelix
is that ganirelix:
(a) Can be given orally
(b) Immediately reduces gonadotropin secretion
(c) Must be given in a pulsatile fashion
(d) Initially stimulates release of LH and FSH
10. Which of the following drugs DO NOT cause hyper -
prolactinemia?
(a) Bromocriptine
(b) Haloperidol
(c) Reserpine
(d) Chlorpromazine
11. A young female, Rama with amenorrhea, infertility and
galactorrhoea was treated with a drug that successfully
restored ovulation and menstruation. Before being
given the drug, the woman was carefully questioned
about previous mental health problems, which she did
not have. She was advised to take the drug orally. The
drug used to treat this patient was probably:
(a) Bromocriptine
(b) Desmopressin
(c) Human gonadotropin hormone
(d) Leuprolide
12. A 47-year old male, Kishore exhibited signs and
symptoms of acromegaly. Radiologic studies showed the
presence of a large pituitary tumor. Surgical treatment
of the tumor was only partially effective in controlling
the disease. At this point, which of the following drugs
is most likely to be used as pharmacological therapy?
(a) Desmopressin
(b) Leuprolide
(c) Octreotide
(d) Somatropin
13. A 7-year old boy, Manoj underwent successful
chemotherapy and cranial radiation for the treatment
of acute lymphocytic leukemia. One month after the
https://kat.cr/user/Blink99/