Review of Pharmacology - 9E (2015)

Review of Pharmacology
Gastrointestinal Tract
(c) 3-5 days
(d) 6-10 days
32. All are H 2
blocker except: (Jharkhand 2003, 2004)
(a) Omeprazole
(b) Cimetidine
(c) Famatodine
(d) Ranitidine
33. The following appears to affect the integrity of the
adherent gel of sucralfate interfering with its action:
(a) Antacids (TN 1991) (AP 2001)
(b) Food
(c) Mucin
(d) Proteins in foodstuffs
34. A patient presents with Zollinger-Ellison syndrome
due to gastrinoma. He has two bleeding ulcers and
diarrhoea. A drug that irreversibly inhibits the H + /K +
ATPase in gastric parietal cells is:
(a) Cimetidine (Karnataka 2007)
(b) Cisapride
(c) Glycopyrrolate
(d) Omeprazole
Anti-emetics and gerd
35. Which of the following is an antagonist of a peptide
and is used to reduce chemotherapy induced nausea
and vomiting?
(a) Atrial natriuretic peptide
(b) Aprepitant
(c) Bradykinin
(d) Enalapril
36. Drug given for metoclopramide induced dystonic
reaction is: (MPPG 2002)
(a) Pheniramine
(b) Promethazine
(c) Chlorpromazine
(d) Prochlorperazine
37. Regarding aprepitant all are true except:
(a) Agonist at NK 1
receptors (AI 2011)
(b) Crosses Blood Brain Barrier
(c) Ameliorate nausea and vomiting induced by chemotherapy
(d) Metabolized by CYP450 enzymes
38. An anti-emetic drug that also decreases acid secretion
due to its action on H 1
receptors is:
(a) Promethazine (AI 2010)
(b) Domperidone
(c) Metoclopramide
(d) Ondansetron
39. Metoclopramide (DPG 2009)
(a) Inhibit cholinergic smooth muscle stimulation in the
gastrointestinal tract
(b) Decrease lower esophageal sphincter pressure
(c) Stimulate D 2
receptor
(d) Enhance colonic motility
40. Drug implicated in prolonging QT interval is:
(a) Domperidone (AI 2004)
(b) Metoclopramide (RJ 2007)
(c) Cisapride
(d) Omeprazole
41. For chemotherapy induced vomiting, 5HT 3
antagonist
having maximum potency is:
(a) Ondansetron (AIIMS Nov., 2007)
(b) Granisetron
(c) Dolasetron
(d) Palonosetron
42. Which of the following drugs is not an antiemetic?
(a) Ondansetron (AIIMS May, 2007)
(b) Domperidone
(c) Metoclopramide
(d) Cinnarizine
43. Anti emetic action is produced through:
(a) Decreased CTZ stimulation (PGI Dec. 2002)
(b) H 1
agonistic action
(c) D 1
antagonistic action
(d) Olfactory apparatus stimulation
(e) 5 HT 4
agonistic action
44. Ondansetron acts by: (PGI June, 2002)
(a) Acting on CTZ
(b) 5-HT 3
antagonism
(c) D 1
and D 2
receptor antagonism
(d) Increasing GIT motility
(e) Blocking cholinergic receptors
45. In case of hill journey, antimotion sickness drugs are
best administered at:
(a) Twelve hours before commencing journey
(b) One hour before commencing journey
(c) Immediately after commencing journey
(d) At the first feeling of motion sickness
46. Metoclopramide has the following actions EXCEPT:
(a) Increase lower esophageal sphincter tone
(b) Prokinetic action is blocked by atropine
(c) Increase gastric peristalsis
(d) Increase large intestinal peristalsis
47. Which of the following prokinetic drugs produces
extrapyramidal side effects?
(a) Metoclopramide
(b) Cisapride
(c) Domperidone
(d) All of the above
48. Which antiemetic drug selectively blocks levodopa
induced vomiting without blocking its anti-
Parkinsonian action?
(a) Metoclopramide
(b) Cisapride
(c) Domperidone
(d) Ondansetron
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