Review of Pharmacology - 9E (2015)

Review of Pharmacology
Hematology
30. Deficiency of this haemophilic factor during early
pregnancy will result in neural tube defect:
(a) Folic acid (Karnataka 2008)
(b) Iron
(c) Cyanocobalamine
(d) Antioxidants
Antiplatelets
31. Which of the following drugs does not act by blocking
Gp IIb/IIIa receptors? (AI 2007)
(a) Abciximab
(b) Eptifibatide
(c) Tirofiban
(d) Clopidogrel
32. In low dose aspirin acts on: (AI 2001)
(a) Cyclooxygenase
(b) Thromboxane A 2
synthase
(c) PGI 2
synthase
(d) Lipoxygenase
33. All of the following statements about clopidogrel are
correct EXCEPT: (AI 2001)
(a) Directly interact with platelet membrane Gp IIb/IIIa
receptor
(b) Onset of action is slow
(c) Duration of action is long
(d) It is used as an alternative to aspirin in patients with
cerebrovascular disease
34. With respect to ticlopidine, clopidogrel:
(a) Is more likely to cause formation of antiplatelet antibodies
(b) Is less likely to cause neutropenia
(c) Is more likely to cause severe bleeding
(d) Has a greater antiplatelet effect
35. A drug that binds to and inhibits Gp IIb/IIIa glycoprotein
and is responsible for platelet antiaggregatory
effects is:
(a) Clopidogrel
(b) Enoxaparin
(c) Fondaparinux
(d) Tirofiban
36. Drugs used in acute myocardial infarction are all
EXCEPT:
(a) Plasminogen activator inhibitors
(b) Thrombolytics
(c) Antiplatelet drugs
(d) Alteplase
37. Which of the following statements regarding ticlopidine
is TRUE?
(a) It blocks GpIIb/IIIa receptors on platelet membrane
(b) It prevents ADP mediated platelet adenylyl cyclase
inhibition
(c) It inhibits thromboxane A 2
synthesis in platelets
(d) It does not prolong bleeding time
38. An old woman, Nanda suffered stroke for which she
was given alteplase. She improved considerably. To
prevent the recurrence of stroke, this patient is most
likely to be treated indefinitely with:
(a) Aspirin
(b) Warfarin
(c) Urokinase
(d) Enoxaparin
39. A patient Amit Kumar is suffering from atherosclerosis.
Which of the following is the most beneficial drug for
prevention of stroke in this patient?
(a) Aspirin
(b) Warfarin
(c) Low dose subcutaneous heparin
(d) Digoxin
40. Aspirin prolongs bleeding by inhibiting the synthesis
of which of the following? (Karnataka 2009)
(a) Adenosine receptors
(b) Cyclic AMP
(c) Prostacyclin
(d) Thromboxane A 2
41. Glycoprotein IIb/IIIa receptor antagonist is:
(a) Clopidogrel (UP 2005)
(b) Abciximab
(c) Tranexamic acid
(d) Ticlopidine
42. All are antiplatelet drugs Except: (UP 2006)
(a) Aspirin
(b) Clopidogrel
(c) Dipyridamole
(d) Warfarin
43. Clopidogrel is an antiplatelet agent that acts by:
(NIMHANS 1991) (TN 2004)
(a) Reducing myocardial oxygen requirements during
exertion and stress
(b) Reducing myocardial oxygen requirements and by
inducing coronary artery vasodilatation
(c) Inhibiting ADP-induced platelet aggregation
(d) None of the above
44. Mechanism of action of aspirin is inhibition of:
(a) Thromboxane A 2
synthesis (TN 2006)
(b) Phosphodiesterase
(c) HMG-CoA reductase
(d) Pancreatic lipase
45. Abciximab is: (RJ 2006, 2005)
(a) Antibody against Ilb/Illa receptors
(b) Antibody against Ib/IX receptors
(c) Topoisomerase inhibitor
(d) Adenosine inhibitor
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