Review of Pharmacology - 9E (2015)

Review of Pharmacology
Chemotherapy A: General Considerations and Non-specific...
83. Which of the following is fourth generation cephalosporin?
(Karnataka 2002)
(a) Cefamandole
(b) Cefpirome
(c) Cephalexin
(d) Cefuroxine
protein synthesis inhibitors
84. Which of the following mechanism is mainly responsible
for gentamicin induced ototoxicity?
(a) Direct hair cell toxicity (AIIMS Nov 2012)
(b) Binding to and inhibition of hair cell Na + K + ATPase
(c) Non-cumulative toxicity
(d) Bind to Ca 2+ channels
85. Tetracycline is used for the prophylaxis of? (AI 2011)
(a) Cholera
(b) Brucellosis
(c) Leptospirosis
(d) Meningitis
86. Which of the following should be monitored if linezolid
is given for more than 14 days? (AI 2010)
(a) Liver function tests
(b) Kidney function test
(c) Platelet count
(d) Audiometry
87. Erythromycin is given in intestinal hypomotility
because: (AIIMS Nov 2009)
(a) It increases bacterial count
(b) It decreases bacterial count
(c) It binds to adenylyl cyclase
(d) It binds to motilin receptors
88. True about aminoglycosides is all except:
(a) Are bacteriostatic (AIIMS May 2008)
(b) Distributed only extracellularly
(c) Excreted unchanged in urine
(d) Teratogenic
89. Which of the following is not true regarding tetracycline?
(AI-2008)
(a) It is not teratogenic
(b) It can cause tooth discoloration
(c) It can result in superinfection
(d) It can lead to pseudomembranous colitis
90. The group of antibiotics that possesses additional antiinflammatory
and immunomodulatory activities is:
(a) Tetracyclines (AI 2005)
(b) Polypeptide antibiotics
(c) Fluoroquinolones
(d) Macrolides
91. All of the following are risk factors for renal toxicity
caused by aminoglycosides EXCEPT: (AI 2002)
(a) Elderly patient
(b) Hypokalemia
(c) Simultaneous use of penicillin
(d) Aminoglycoside administration in recent past
92. Tetracyclines inhibit protein synthesis by:
(AI 2001, AIIMS Nov, 2005)
(a) Inhibition of initiation and misreading of mRNA
(b) Binding to 30 S subunit and inhibiting the binding of
aminoacyl-tRNA to A site
(c) Inhibiting peptidyl transferase activity
(d) Inhibiting translocation
93. The antibiotic that inhibits protein synthesis by premature
termination and which structurally resembles
amino acyl t-RNA is:
(a) Tetracycline (DPG 2009) (AIIMS Nov, 2002)
(b) Chloramphenicol
(c) Puromycin
(d) Erythromycin
94. Ototoxicity of aminoglycoside is increased with
concurrent use of which of the following drug (s):
(a) Cisplatin (PGI Dec. 2004)
(b) Furosemide
(c) Vancomycin
(d) Vincristine
(e) Erythromycin
95. Which one of the following statements about doxycycline
is FALSE?
(a) It is bacteriostatic
(b) It is excreted mainly in the feces
(c) It is more active than tetracycline against H.pylori
(d) It is used in Lyme’s disease
96. Concerning streptogramins, which one of the following
statements is FALSE?
(a) They are active against methicillin-resistant staphylococci
(b) They may cause a syndrome of arthralgia and myalgia
(c) They induce formation of hepatic drug metabolizing
enzymes
(d) They are used in the management of infections
caused by vancomycin-resistant enterococci
97. Which of the following statements about the clinical
uses of the aminoglycosides is FALSE?
(a) Owing to their polar nature, aminoglycosides are not
absorbed following oral administration
(b) Aminoglycosides are often used in combination with
cephalosporins in the empirical treatment of lifethreatening
bacterial infections
(c) The spectrum of antimicrobial activity of aminoglycosides
includes Bacteroides fragilis
(d) Gentamicin is used with ampicillin for synergistic
effects in the treatment of enterococcal endocarditis
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