Review of Pharmacology - 9E (2015)
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Review of Pharmacology - 9E (2015)

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Chemotherapy A: General Consideration and Non-specific Antimicrobial Agents<br />

130. Which <strong>of</strong> the following statements about sulfonamides<br />

is FALSE?<br />

(a) Sulfonamides inhibit bacterial dihydr<strong>of</strong>olate reductase<br />

(b) Dysfunction <strong>of</strong> the basal ganglia may occur in the<br />

newborn if sulfonamides are administered late in<br />

pregnancy<br />

(c) Sulfonamide crystalluria is most likely to occur at<br />

low urinary pH<br />

(d) Sulfonamides are antimetabolites<br />

131. Which <strong>of</strong> the following statements about the fluoroquinolones<br />

is FALSE?<br />

(a) Gonococcal resistance to fluoroquinolones may<br />

involve changes in DNA gyrase<br />

(b) Modification <strong>of</strong> fluoroquinolones dosage is required<br />

in patients if creatinine clearance is less than 50 mL/<br />

min<br />

(c) A fluoroquinolone is the drug <strong>of</strong> choice for treatment<br />

<strong>of</strong> an uncomplicated urinary tract infection in a 7<br />

year-old girl<br />

(d) Fluoroquinolones inhibit relaxation <strong>of</strong> positively<br />

supercoiled DNA<br />

132. Which <strong>of</strong> the following adverse effects is most likely to<br />

occur with sulfonamides?<br />

(a) Neurologic effects including headache, dizziness,<br />

and lethargy<br />

(b) Hematuria<br />

(c) Fanconi’s anemia<br />

(d) Skin reactions<br />

133. Which fluoroquinolone is highly active against<br />

Mycobacterium leprae and is being used in alternative<br />

multidrug therapy regimens:<br />

(a) Norfloxacin<br />

(b) Ofloxacin<br />

(c) Cipr<strong>of</strong>loxacin<br />

(d) Lomefloxacin<br />

134. Maximum incidence <strong>of</strong> phototoxicity is associated with:<br />

(a) Norfloxacin<br />

(b) Sparfloxacin<br />

(c) Lomefloxacin<br />

(d) Cotrimoxazole<br />

tahir99 - UnitedVRG<br />

135. Methanamine salts are used as urinary antiseptics. The<br />

reason they lack systemic antibacterial action is that<br />

they are:<br />

(a) Not absorbed into systemic circulation after oral use<br />

(b) Rapidly metabolized by liver drug metabolizing<br />

enzymes<br />

(c) Converted to formaldehyde at low urinary pH<br />

(d) Substrates for active tubular secretion<br />

136. A contraindication to the use <strong>of</strong> cipr<strong>of</strong>loxacin is a history<br />

<strong>of</strong>:<br />

(a) Epilepsy<br />

(b) Deep vein thrombosis<br />

(c) Gout<br />

(d) G-6 PD deficiency<br />

137. The combination <strong>of</strong> trimethoprim and sulfamethoxazole<br />

is effective against which <strong>of</strong> the following opportunistic<br />

infections in the AIDS patient?<br />

(a) Disseminated Herpes simplex<br />

(b) Cryptococcal meningitis<br />

(c) Pneumocystis jiroveci<br />

(d) Tuberculosis<br />

138. Cipr<strong>of</strong>loxacin should not be given to an asthmatic using<br />

theophylline because: (DPG 2003)<br />

(a) Cipr<strong>of</strong>loxacin inhibit theophylline metabolism<br />

(b) Theophylline inhibits cipr<strong>of</strong>loxacin metabolism<br />

(c) Cipr<strong>of</strong>loxacin decreases effect <strong>of</strong> theophylline<br />

(d) Theophylline induces metabolism <strong>of</strong> cipr<strong>of</strong>loxacin<br />

139. Mechanism <strong>of</strong> action <strong>of</strong> fluoroquinolones is:<br />

(a) Inhibits cell wall synthesis (UP 2005 (DPG 2000)<br />

(b) Inhibits protein synthesis<br />

(c) Inhibits DNA gyrase<br />

(d) Interferes with intermediary metabolism<br />

140. Eye drops <strong>of</strong> which sulphonamide is used clinically?<br />

(a) Sulfacetamide (MH 2000)<br />

(b) Sulfamethoxazole<br />

(c) Sulfinpyrazone<br />

(d) All<br />

141. Which is <strong>of</strong> the following can be used safely in renal<br />

failure? (Kolkata 2005)<br />

(a) Cipr<strong>of</strong>loxacin<br />

(b) Ofloxacin<br />

(c) Lomefloxacin<br />

(d) Pefloxacin<br />

clinical uses <strong>of</strong> antimicrobials<br />

142. Drug-induced colitis is most frequently associated<br />

with: (AIIMS May 2012)<br />

(a) Neomycin<br />

(b) Vancomycin<br />

(c) Clindamycin<br />

(d) Chloramphenicol<br />

143. A 26 year old patient presents with suspected pneumococcal<br />

meningitis. CSF culture is sent for antibiotic<br />

sensitivity. Which empirical antibiotic should be given<br />

till culture sensitivity result come? (AIIMS May 2012)<br />

(a) Penicillin G<br />

(b) Ceftriaxone + metronidazole<br />

(c) Doxycycline<br />

(d) Cefotaxime + vancomycin<br />

144. A patient develops an infection <strong>of</strong> methicillin resistant<br />

Staphylococcus aureus. All <strong>of</strong> the following can be used<br />

to treat this infection except: (AI 2012)<br />

(a) Cotrimoxazole (AIIMS Nov. 2011)<br />

(b) Cefaclor<br />

(c) Cipr<strong>of</strong>loxacin<br />

(d) Vancomycin<br />

547<br />

Chemotherapy A: General Considerations <strong>Pharmacology</strong> and Non-specific...<br />

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