AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
4. ECOTOXICITY ID: 7783-20-2
DATE: 18.04.2006
Species:
other: Channa punctatus
Endpoint:
other: testicular development
Exposure period: 6 month
Unit: mg/l Analytical monitoring: no
LOEC: = 100
Method:
GLP:
Test substance:
Result:
other: see Test Condition
no
other TS: ammonium sulfate fertilizer, not further specified
In testes of the 100 ppm group, spermatogenesis did not
progress beyond spermatocyte stage and sperm were totally
absent. Necrosis of spermatogenic elements and other effects
were also noted. In the 500 ppm group, testes
exhibiteddisorganization of lobules, significant inhibiton of
spermatogenesis, extensive necrosis, and disintegration of
spermatogenic elements. The gonado-systemic indices (=total
gonad weight : total body weight x 100) were significnatly
reduced in the 100 ppm (0.125) and 500 ppm (0.117) treated
groups relative to the ocntrol (0.166).
Correlative histological changes were also observed in the
pituitary gonadotrophs, in fish of both experimental
groups, being smaller, involuted, inactive and less in
number. The authors concluded that ammonium sulfate is
inhibiting testicular development and inducing deleterious
changes in spermatogenic elements either by direct action on
the testis itsself or indirectly via the
hypothalamic-pituitary- testicular axis in this species.
Test condition: Thirty adult C. punctatus were divided between 100 ppm, 500
ppm and control aquariums in well water at pH 7.2. Water
changes were made on alternate days after feeding fish with
minced goat liver.
The experiments were run from the first week in January
(when testes were in resting condition containing only
spermatogonia), and ended the last week of June (when
control testes were in mature spawning conditions).
Reliability: (2) valid with restrictions
Flag:
Critical study for SIDS endpoint
26-JAN-2004 (90)
Species:
Endpoint:
Unit:
Method:
GLP:
Test substance:
Result:
Oncorhynchus gorbuscha (Fish, fresh water)
other: length of fish, weight of fish
Analytical monitoring: yes
other: see Test Condition
no data
other TS: ammonium sulfate, not further specified
NOEC (61 d) = 1.2 mg un-ionized NH3/L (length, weight of fry).
LOEC (61 d) = 2.4 mg un-ionized NH3/L (length, weight of fry).
The highest concentration of ammonia caused significant
decreases in weight of exposed fry in all three exposure
groups. At 2.4 ppb un-ionized ammonia, the groups held for
40 and 61 days were significntly smaller in length and
weight but at 1.2 ppb un-ionized ammonia there was no
significant difference. Effects were consistently more
adverse for groups held 61 days.
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