AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
different batches (cf Test Condition).
Result:
Single exposure for 20 hours, intact skin: no skin effects
observed.
Multiple exposures, 8 hrs/day for 5 consecutive days, intact
skin: no skin effects observed.
Single exposure for 8 hours, scarified skin: slight redness,
slight edema; completely reversible within 8 days. NaCl
induced strong erythema, strong edema and necroses, and
distilled water slight redness in these experiments.
Test condition: The neat test substance (about 1.0 g) was applied on
moistened patches (about 2.5 x 2.5 cm in size) to the intact
back skin of white rabbits. Exposure time was either 20 hours
or 8 hours each on 5 consecutive days. In another test the
test substance was applied in the same manner as
described above to scarified skin for 8 hours. Skin treated
with distilled water or NaCl served as control in the
experiments on scarified skin.
The tests on intact skin were performed with 12 different
batches of the test substance. Four of the batches contained
0.03% anti-caking material.
The tests on scarified skin were performed with 8 different
batches of the test substance. None of the batches contained
anti-caking material.
Number of animals tested: not reported.
Reliability: (2) valid with restrictions
limited documentation, no information on purity
Flag:
Critical study for SIDS endpoint
18-NOV-2003 (127)
5.2.2 Eye Irritation
Species:
Concentration:
Dose:
Vehicle:
Result:
rabbit
undiluted
50 other: mm3
none
not irritating
Method:
other: see Test Condition
Year: 1969
GLP:
no
Test substance: other TS: as prescribed by 1.1 - 1.4, "chemically pure"
Result:
Test condition:
162
Slight edema and conjunctival redness was noted at 1 hour
after instillation of the test substance; no edema, but
still slight redness was present at 24 hours. In the eyes
treated with talcum, slight redness was also noted at 1 and
24 hours after exposure. No effects were noted at day 8.
According to "Description of methods used in BASF acute
toxicity and skin/eye irritation studies before pertinent
OECD/EU test guidelines were in place" (BASF AG, 2002)
TEST ORGANISMS: Rabbits, White Vienna strain. 2 Animals.
EXPOSURE TO TEST SUBSTANCE:
Undiluted test substance was instilled into one eye of
rabbits, the other eye was treated in the same way with 50
mm3 of talcum and served as control. The eyes were not
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