AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
activities of lactate-dehydrogenase, acid-phosphatase, and
N-acetyl-beta-D-glucosaminidase 135, 135, and 155%,
respectively. The addition of ammonium sulfate caused no
significant change from the above values with ozone, ammonium
sulfate had no synergistic effect on tissue protein or DNA
content.
Exposure to ammonium sulfate alone did not increase the
protein content of the BAL.
Test condition:
The described synergistic effect of ozone and ammonium sulfate
seems to be questionable, since only the middle dose of 0.2
ppm ozone was tested for this endpoint, it is not stated if
the other ozone concentrations were not tested or did not show
an effect. From the discussion one might interpret that also
the combination of 0.64 ppm ozone and ammonium sulfate was
tested without showing a synergistic effect.
Pulmonary changes in rats induced by ozone and the
synergistic effects of ammonium sulfate were studied.
Male Sprague-Dawley rats were exposed to 0.12, 0.20, 0.40,
and 0.64 ppm of ozone and 5 mg/m3 of ammonium sulfate
aerosol of 0.5 µm MMAD for up to 7 days (23,5h/day).
Furthermore animals were exposed 2 days to ammonium sulfate
aerosol alone.
Reliability: (4) not assignable
only one concentration tested, no histological examination,
the main examinations refer to ozone, only data of combination
exposure are given in this publication, partly insufficient
description
10-APR-2006 (131)
Type:
Sub-acute
Species: rat Sex: male
Strain:
Sprague-Dawley
Route of administration: inhalation
Exposure period:
5 or 20 days
Frequency of treatment: 6 hours/day, 5 days/week
Post exposure period: no
Doses: 1 mg/m3 (MMAD 0.4 um, geometric standard deviation 2.2)
Control Group:
other: filtered air
Method:
GLP:
Test substance:
Remark:
Result:
170
other: see Test Condition
no data
other TS: ammonium sulfate, reagent grade
In this study, animals with elastase-induced pulmonary
emphysema and saline-treated controls were used to determine
if lung function changes related to ammonium sulfate exposure
were greater (compared with controls) in animals with
experimentally induced emphysema. Only the results for
ammonium sulfate exposure vs. air controls are reported in
detail.
Results from 27-29 animals/group are reported. No
information is provided on mortality.
Body weight was not affected by aerosol exposure. In ammonium
sulfate exposed rats, values for lung residual volume and
functional residual capacity were significantly larger than
comparable values measured in air-exposed animals. This
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