AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Exposure period: 24 hours after injection
Doses:
single injection: 0; 62.5; 125; 250; 500 mg/kg; four
injections within 24 h: 31.3; 62.5; 125; 250 mg/kg
Result:
negative
Method:
other
GLP:
no data
Test substance: other TS: Ammonium chloride, purity 99.7%
Remark:
There are no in vivo data on genotoxicity for ammonium
sulfate. To bridge the data gap, data for ammonium chloride,
which dissociates in aqueous media to form ammonium ions, as
does ammonium sulfate, will be used. However, data on sulfate
ions are not available.
Result: MNPCE: single injection: 0.12 %; 4 injections: 0.17 %
Test condition: - The maximum dose of ammonium chloride was determined by
pilot experiments using the multisampling at multi-dose levels
method.Dose up to MTD (maximum tolerated dose) were used.
-Mice were killed 24hr after an administration.
-Femural marrow cells were flushed out with fetal bovine serum
and fixed with methanol and stained with Giemsa.
-One thousand polychromatic erythrocytes per mouse were scored
using a light microscope and the number of micronucleated
erythrocytes (MNPCE) was recorded.
Reliability: (2) valid with restrictions
Flag:
Critical study for SIDS endpoint
10-APR-2006 (146)
5.7 Carcinogenicity
Species: rat Sex: male
Strain:
Fischer 344/DuCrj
Route of administration: gavage
Exposure period:
16 hours
Frequency of treatment: single treatment
Doses:
0, 500, 1000, 1500 or 2660 mg ammonium sulfate/kg bw
(7.56-20.1 mM/kg bw) in a volume of 0.5-1 mL by stomach
tube
Control Group:
yes, concurrent no treatment
Method:
other: see Test Condition
Year: 1989
GLP:
no data
Test substance: other TS: ammonium sulfate, reagent grade (Wako Pure
Chemicals, Osaka)
Remark:
Result:
194
These data need careful evaluation as high salt
concentrations were given as a bolus dose directly into
the stomach. It is known that high salt concentrations can
denature proteins leading to cell injury or cell death.
Subsequently cell proliferation might occur as a repair
mechanism causing an increase in ornithine decarboxylase in
the glandular stomach.
The effect of various salts including ammonium sulfate on
ornithine decarboxylase in rat stomach mucosa is
reported.
A 73 fold increase in ornithine decarboxylase activity was
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