AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
rinsed.
OBSERVATIONS: Eyes were examined at 1 hour, 24 hours and
several times thereafter until 8 days after instillation.
Reliability: (2) valid with restrictions
limited documentation, no further information on purity
Flag:
Critical study for SIDS endpoint
10-APR-2006 (111)
5.3 Sensitization
5.4 Repeated Dose Toxicity
Type:
Sub-acute
Species: rat Sex: male
Strain:
no data
Route of administration: inhalation
Exposure period:
up to 14 days
Frequency of treatment: 8 hours/day
Post exposure period: no
Doses:
300 mg/m3
Control Group:
other: air
Method:
GLP:
Test substance:
Result:
Test condition:
other: see Test Condition
no data
other TS: ammonium sulfate, not further specified
No effects on arterial blood gases, pH and bicarbonate
levels in blood were found. No effect was noted on residual
volume and vital capacity of the lung. Trachea, bronchial
lymph nodes and lungs showed no histopathological changes.
The body weights of the animals were unaffected.As the
respiratory tract is the target organ, the NOEL for the lower
respiratory tract is 300 mg/m3
The study was designed to measure arterial blood gases in
rats (10 adult males/group) after inhalation of 300 mg/m3
ammonium sulfate for 1, 3, 7 or 14 days, 8 h/day. Pulmonary
function tests were performed in animals after 14 days of
exposure.
Microscopic examinations of the lung were also performed.
The concentrations used were determined on basis of the
results from a preliminary study with rats were exposed to
the maximum attainable concentration of ammonium sulfate
using the same equipment and methods, i.e. a group of 6 male
rats were exposed 8 h/day for 3 consecutive days to a
concentration of 1000-1200 mg/m3. No toxicological effects
were noted in this pretest.
Ammonium sulfate aerosol was generated from an aqueous
solution with Retec nebulizers and dried by mixing with dry
air and passing it through a heated glass tube. Ammonium
sulfate concentration was determined by collecting the
aerosol on a glass fiber filter at a flow rate of 2 L/min
for 15 minutes and weighing the filter. Accuracy of the
method was periodically checked by chemical analysis of the
filter sample. Particle size was evaluated gravimetrically
using an Andersen multi-stage sampler. The particle size was
between 1 and 2 um in diameter.
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