AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
first parity
gestation: ca. 1790-2190 mg sulfate/kg bw
lactation: ca. 3680-5360 mg sulfate/kg bw
second parity
gestation: ca. 2025-2610 mg sulfate/kg bw
lactation: ca. 3910-6560 mg sulfate/kg bw
Reliability: (2) valid with restrictions
limited documentation, low numbers of animals per dose group,
only females were treated, no fertility indices were measured.
Flag:
Critical study for SIDS endpoint
14-JUN-2004 (149)
Type:
Species:
Sex:
Strain:
Route of administration:
Exposure Period:
Frequency of treatment:
Doses:
other
rabbit
female
no data
oral unspecified
5-16 months
on alternate days
100-200 mg/kg bw
Method:
GLP:
Test substance:
other: see Test Condition
no
other TS: ammonium sulfate, not further specified
Result:
Treatment of virgin female rabbits with ammonium carbonate,
chloride, hydrophosphate, sulfate, or hydroxide at 100-200
mg/kg bw, orally, on alternate days, for periods of 3 weeks
separated by 1-week intervals of no treatment, was
associated with enlargement of the ovaries, follicle
maturation, and formation of corpora lutea. There was also
enlargement of the uterus, hypertrophy of the breast, and
secretion of milk. (no information as to the incidence and
magnitude of the effect reported).
Reliability: (4) not assignable
Secondary citation. No further details available (it was not
possible to retrieve the original paper).
10-APR-2006 (150)
Type:
Species:
Sex:
Strain:
Route of administration:
Exposure Period:
Frequency of treatment:
Premating Exposure Period
male:
female:
Duration of test:
Doses:
Control Group:
other: NOAEL, reproductive toxicity :
= 1500 mg/kg bw
other: NOAEL, developmental toxicity :
= 1500 mg/kg bw
other: reproductive/developmental toxicity screening
test
rat
male/female
other: CD
gavage
see Test Condition
see Test Condition
2 weeks
2 weeks
see Test Condition
0, 250, 750, 1500 mg/kg bw/day
yes, concurrent vehicle
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