AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Flag:
Critical study for SIDS endpoint
21-JUN-2004 (121)
Type:
Species:
Vehicle:
Doses:
Exposure time:
other: pulmonary functional response
guinea pig
other: Aerosol
1 mg/m3 (0.7um MMAD)
1 hour(s)
Method:
other
Year: 1977
GLP:
no
Test substance: other TS: Ammonium sulfate
Method: 12 female guinea pigs inhaled via intratracheal catheter 1
mg/m3 ammonium sulfate (MMD 0,7 um) for 1 hour. The recovery
time was 1/2 hour. 14 control animals were
exposed with to air only. Lung function measurements were
performed. Dynamic lung compliance (Cdyn) and pulmonary flow
resistance (RL) were calculated.
The animals were killed and examined (lungs for evidence of
gross injury caused by catheter and for diseases).
The average values of the functional measurements for the
control, exposure, and recovery time were reported.
Result:
The comparison of Cdyn and RL values during control period and
exposure within each animal showed changes of these parameters
in a fraction of the exposed population.
The changes were only slight and comprised increases and
decreases.
Overall a decrease in Cdyn of 2% and an increase in RL of 7%
were found.
Reliability: (2) valid with restrictions
no common test system, high interanimal variability, no
information on test substance purity.
10-APR-2006 (122)
Type:
Species:
Strain:
Sex:
Doses:
Exposure time:
Method:
GLP:
Test substance:
other: effect on pulmonary function
other: donkey
no data
no data
0.4 - 2.1 mg/m3
1 hour(s)
other: see Test Conditions
no
other TS: (NH4)2SO4, purity not stated
Remark:
Result:
Because of the great variability in the intraanimal control
measurements, a change in flow resistance of more than 25%
was needed to detect a significant alteration caused by the
exposure.
No effects on pulmonary flow resistance or dynamic
compliance were seen.
Test condition: 4 donkeys were exposed to ammonium sulfate aerosols (0.4-2.1
mg/m3) for 1 hour.
The median aerodynamic diameter (MAD)was 0.4 um.
Reliability:
(3) invalid
UNEP PUBLICATIONS 155