AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
10-APR-2006 (163)
Endpoint:
other: synergistic effects of ozone or nitrogen and
ammonium sulfate
Species:
rat
Strain: Sprague-Dawley Sex: male
Remark:
A hitherto unexpected synergism between the oxidant air
pollutants ozone or nitrogen dioxide and respirable-size
aerosol of ammonium sulfate was observed during controlled
exposure of rats to these substances. in this experiment were
examine biochemical and morphometric changes in lungs of rats
exposed for 3,7 or 14 days to ozone (0.64-0.96 ppm) with and
without of ammonium sulfate aerosol (diameter of ca. 1 um, 5
mg/m3).
After 3 days of mixture exposure, rat lung macrophage
precursors (monocytes) increased 2-3 fold, fibroblasts were
increased 2 fold, and apparent collagen synthesis rats were
increased 2.5 fold, as compared with values from animals
exposed to ozone alone. Continued exposure to ozone alone for
7 or 14 days seemed to mimic changes seen 3 days with the
mixture of pollutants Total number of lesions per lung was the
same for ozone exposure with and without accompanying aerosol;
lesions were larger in lungs of rats exposed to ozone plus
ammonium sulfate. The authors suggest that the lifetime of
free radicals arising from interaction of oxidants such as
ozone or nitrogen dioxide with normal molecules within the
lung is increased by either local pH changes in the local
sulfate concentration caused by inhalation of respirable
aerosol.
Ammonium sulfate alone did not increase the collagen synthesis
in lung minces of exposed rats, however, exposure time was not
given.
Reliability: (1) valid without restriction
application mixtures from ammonium sulfate, ozone and nitrogen
oxide, exposure time not given
12-APR-2006 (164) (165) (166) (167)
Endpoint:
other: screening in vitro of pulmonary toxins
Remark:
A short-term (20h) culture of functionally competent
(nitrotetrazolium reductase positive) Clara cells was
developed. In this culture the Clara cells were allowed to
attach to an extracellular matrix in 96 multiwell plates .
Ammonium sulfate were examined for the ability to reduce the
attachment efficiency of functionally competent Clara cells
and TD50 values were calculated. Ammonium sulfate had no
effect to attachment.
Reliability: (3) invalid
no detailed information of results
14-JUN-2004 (168)
Endpoint:
Species:
other: Clearance system: role of exposure
concentration, time and relative acidity
rabbit
UNEP PUBLICATIONS 209