AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
(MCV), mean erythrocyte hemoglobin (MCH),
mean erythrocyte hemoglobin concentration (MCHC), platelet
count, and leukocyte count.
STATISTICAL METHODS: Bartlett, and Kruskal-wallis tests, and
parametric Dunnett and Scheffe tests.
YEAR Of STUDY: not reported.
Conclusion: Male animals in the 3% group exhibited diarrhea during the
administration period. No changes indicating obvious
ammonium sulfate toxicity were observed in the body weights,
organ weights, hematological, serum biochemical, or
histopathological examinations.
Based on these results, the NOEL was judged to be 1.5% in
males (886 mg/kg bw/day) and 3% in females (1975 mg/kg
bw/day).
Reliability: (2) valid with restrictions
low number of organs examined histopathologically as compared
to a guideline study
Flag:
Critical study for SIDS endpoint
10-APR-2006 (134)
Type:
Sub-chronic
Species: mouse Sex: male
Strain:
Balb/c
Route of administration: drinking water
Exposure period:
1 month
Frequency of treatment: continuously
Post exposure period: no
Doses:
0.611 g/L ammonium sulfate (corresponding to 250 ppm
ammonium)
Control Group:
yes, concurrent vehicle
Method:
GLP:
Test substance:
Remark:
Result:
Test condition:
other: see Test Condition
no data
other TS: ammonium sulfate, not further specified
The study was undertaken to investigate the role of
cytokines involved in aluminum neurotoxicity. Animals were
treated with aluminum ammonium sulfate at different dose
levels, and an additional group of animals received ammonium
sulfate in order to determine whether ammonium or sulfate
ions affected the results.
There were no treatment-related effects on final body weight
and on liver, kidney, and spleen weights, normalized to the
body weight. No signs of gross behavioral alterations were
observed in any animal during the treatment period. There
were also no significant differences among controls and
treatment groups in weight gain. The food consumption was
4.52 g/mouse per day for the control, and 4.63 g/mouse per
day for the ammonium sulfate-treated group. Mean water
consumption was 4.574 +/- 0.182 mL/mouse per day for
controls, and 4.484 +/- 0.081 mL/mouse per day for ammonium
sulfate treated animals.
There were no significant differences for any cytokine
between the control and ammonium sulfate treated groups (TNF
alpha, IL-1beta, IFN-gamma, and beta-actin in the cerebrum),
whereas aluminum treated groups demonstrated a significant
increase of relative expression of TNFalpha in the cerebrum.
TEST ORGANISMS: adult, 7-8 week old, male BALB/c mice from
UNEP PUBLICATIONS 177