AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
started to increase at 10 min after ingestion and its level<br />
continued to increase linearly to <strong>20</strong> mEq/l.<br />
Test condition: Five Japanese white rabbits, weighing 3.4 to 3.8 kg were<br />
used. The animals were anesthetized with intravenous<br />
pentobarbital sodium (12.5 mg/kg bw), injected in auricular<br />
veins, and supplemental doses were intermittently given to<br />
maintain surgical level of anesthesia. Rabbits were fixed in<br />
supine position and a double channel catheter was placed in<br />
the femoral artery to draw blood samples. The total dose of<br />
1500 mg/kg ammonium sulfate (dissolved in saline solution) was<br />
administered in 10-15 mL of volume per rabbit through gastric<br />
probe in three rabbits. 2 rabbits were administered 10-15 mL<br />
of saline and used as controls.<br />
Blood samples were collected from the femoral artery 5 min<br />
before and 10 min after and every 15 minutes up to 90 minutes<br />
after administration of ammonium sulfate solution.<br />
The serum level of ammonium ion was measured.<br />
Inorganic sulfate ions in serum were measured by ion<br />
chromatography.<br />
Reliability: (2) valid with restrictions<br />
limited documentation<br />
Flag:<br />
Critical study for SIDS endpoint<br />
10-APR-<strong>20</strong>06 (105)<br />
In Vitro/in vivo:<br />
Type:<br />
Species:<br />
In vitro<br />
Metabolism<br />
rat<br />
Result:<br />
In vitro addition of ammonium chloride to rat liver slices<br />
produced an increase in urea synthesis of 38%. No additional<br />
increase in the production of urea was found in liver slices<br />
prepared from rats injected intraperitoneally with 10.6 mmol<br />
NH4-N/kg as ammonium sulfate and incubation of ammonium<br />
chloride. (Significant increases were found in slices from<br />
rats treated with equimolar amounts of arginine, citrulline<br />
and ornithine in<br />
the presence or absence of ammonium sulfate.)<br />
Reliability: (4) not assignable<br />
insufficient data to allow assessment<br />
10-APR-<strong>20</strong>06 (106)<br />
In Vitro/in vivo:<br />
Type:<br />
In vivo<br />
Absorption<br />
Remark:<br />
Reliability:<br />
Flag:<br />
Evidence exists for the active transport of the ammonium ion<br />
from the intestinal tract. It was shown that ammonia<br />
transport by the human colon still occurred when the luminal<br />
pH was reduced to 5, at which value non-ionized ammonia<br />
would be virtually absent.<br />
(2) valid with restrictions<br />
reliable review<br />
Critical study for SIDS endpoint<br />
UNEP PUBLICATIONS 143
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