AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Species:
Value:
rat
= 3000 - 4000 mg/kg bw
Reliability: (4) not assignable
secondary citation
20-APR-2003 (114)
Type:
Species:
Value:
LD50
mouse
= 640 mg/kg bw
Reliability: (4) not assignable
secondary citation
17-MAR-2003 (112)
Type:
Species:
Strain:
Sex:
Vehicle:
Doses:
Value:
LD50
mouse
other: ddy
male/female
water
full LD50 test, 2670-3440mg/kg bw; screening test: 2000 mg/kg
bw (limit test)
= 3040 mg/kg bw
Method:
other: according to TG 423 (screening) and TG 401 (full test)
Year: 1984
GLP:
no data
Test substance: other TS: ammonium sulfate, commercial grade
Remark:
Result:
The study was undertaken to validate a screening test for
the assessment of the acute oral toxicity with a view to
minimizing the use of animals in the acute toxicity testing.
Two laboratories cooperated in this study.
Results from full LD50 test:
LD50 = 3040 mg/kg bw (2670 - 3440 mg/kg bw)
Results from the screening test:
Approximative LD50 in males:
in laboratory A > 2000 mg/kg bw,
in laboratory B > 2000 mg/kg bw
Approximative LD50 in females:
in laboratory A > 2000 mg/kg bw,
in laboratory B > 2000 mg/kg bw.
Test condition:
148
Clinical signs, necropsy findings: not reported.
The full LD50 test was performed according to the Toxicity
Guidelines of Japan (Ministry of Health and Welfare in Japan
1984)
For the screening study, male and female ddy mice of 5-6
weeks of age were treated with the test substance after at
least 5 days of adaptation. The test substance was
administered orally in a single dose after fasting for 16
hours.
Observation of animals, including body weight changes,
mortality, gross lesion and behavioural and clinical
abnormality, were performed for 14 days after exposure, and
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