AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Method: other: OECD TG 471 (1983)
Year: 1989
GLP:
no
Test substance: other TS: as prescribed by 1.1 - 1.4, purity 99.5%
Result:
In none of the experiments was an increase in the mutation
frequency observed. Cytotoxic effects were not found. The
positive controls were functional and showed a distinct
increase in mutation frequencies.
Test condition: A standard plate test and a pre-incubation test were
performed within this study, both with and without a
metabolic activation system (liver S-9 mix from Aroclor 1254
induced male rats).
Solvent: distilled water
Negative controls: solvent control, sterility control.
Positive controls:
- 2-aminoanthracene (10 ug, dissolved in DMSO), for
experiments with S-9 mix in TA100, TA98, TA1537 and TA1535
- N-methyl-N´-nitro-N-nitroso-guanidine (MNNG, 5 ug
dissolved in DMSO), for experiments without S-9 mix in TA100
and TA1535
- 4-nitro-o-phenylendiamine (10 ug, dissolved in DMSO) for
the experiments without S-9 mix in TA98
- 9-aminoacridine chloride monohydrate (100 ug, dissolved in
DMSO) for the experiments without S-9 mix in TA1537.
Evaluation criteria:
A substance was considered positive in this test if the
following was fulfilled:
- doubling of the spontaneous mutation rate (control)
- dose-response relationship
- reproducibility of the results.
Reliability: (1) valid without restriction
Flag:
Critical study for SIDS endpoint
18-NOV-2003 (138)
Type:
Ames test
System of testing: Salmonella typhimurium TA1535 TA1537 TA1538
Concentration:
25,000 and 50,000 ppm (2.5, 5%; 25, 50 mg/mL) for
suspension tests; 50,000 ppm (5%; 50 mg/mL) in plate
test
Cytotoxic Concentration: not cytotoxic
Metabolic activation: with and without
Result:
negative
Method:
other: standard plate and suspension tests
Year: 1975
GLP:
no data
Test substance: other TS: ammonium sulfate granular food grade
Remark:
Test condition:
all positive controls were functional.
A standard plate test and a suspension test were performed
within this study, both with and without a metabolic
activation system (liver S-9 mix from male rats; additionally
lung and testes S-9 supernatants from male rats, ICR mice
and rhesus monkey were used as well as liver S-9 from mice
and monkeys for the activation experiments).
Solvent: saline.
Negative controls: solvent control.
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