AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Method: OECD Guide-line 422
Year: 2002
GLP:
yes
Test substance: other TS: diammonium phosphate, not further specified
Result:
200
Treatment at all dosages was well tolerated and there were
no treatment-related deaths.
A dosage dependent increase in transient post-dosing
salivation was apparent, which was considered to be due to
the palatability of the test formulations rather than
toxicity. A dosage-dependent increase in the number of
animals with reddening of the extremities was also apparent
mainly during the early stages of treatment.
Body weight gain and food consumption of males at 1500 mg/kg
bw/day appeared to be suppressed when compared with the
control group, such that gain between weeks 0-5 for this
group was 78% of controls. The body weight gain for
reproductive subgroup females receiving 1500 mg/kg bw/day
was reduced during the first week of gestation, after which
the values returned to levels comparable with the control.
Some treatment-related effects on hematology were evident
(reduction in activated partial thromboplastin time for
males at 750 and 1500 mg/kg bw/day, a non dosage-dependent
elevation of alkaline phosphatase levels at 750 and 1500
mg/kg bw/day, reduced glucose and phosphorous levels at 1500
mg/kg bw/day, a dosage-dependent reduction in total protein at
750 and 1500 mg/kg bw/day with a slight elevated
albumin/globulin ratio at the top dosage. Changes in females
were limited to a decrease in phosphorous levels and a
non-significant increase in alkaline phosphatase level at
1500 mg/kg bw). Relative kidney and liver weights for
females at 1500 mg/kg bw/day were greater than in the
control group, but there were no histological changes
associated.
A number of treated animals at 750 and 1500 mg/kg bw/day
exhibited horizontal banding on the incisors at necropsy;
histological processing of these tissues failed to detect
any change in the areas examined suggesting that the banding
was restricted to the enamel of the teeth. The only
histological findings related to treatment were the
inflammatory/degenerative stomach changes in all treated
groups that were considered likely to have arisen due to an
irritant effect of the test formulations.
There were no changes apparent at behavioral testing.
Mating performance and fertility were unaffected by
treatment, and parental treatment had no apparent effect on
the offspring to day 4 of age.
Summary of effects on reproduction/development (control,
low, mid, high dose):
Females achieving pregnancy: n= 9, 10, 10, 10.
Dams with live young born: n = 9, 10, 10, 10.
Implants/dam (mean): 15.7, 15.7, 14.1, 15.4.
Live pups/dam at birth (mean): 14.8, 14.6, 12.7, 14.0.
Live pups/dam at day 4 (mean): 14.6, 14.3, 12.7, 14.0.
sex ratio (% m) at birth (mean): 54.2, 52.7, 50.0, 48.5.
sex ratio (%m) at day 4 (mean): 54.2, 53.0, 50.0, 48.5.
Male pup weight at birth (mean): 6.4, 6.3, 6.6, 6.3.
Male pup weight at day 4 (mean): 8.7, 8.5, 9.2, 8.7.
Female pup weight at birth (mean): 5.9, 6.0, 6.1, 6.0.
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