AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
5.0 Toxicokinetics, Metabolism and Distribution<br />
In Vitro/in vivo:<br />
Type:<br />
Species:<br />
In vivo<br />
Excretion<br />
other: hamster, guinea pig, rabbit<br />
Result: It was demonstrated that the particles with a size of 0.3<br />
and 0.6 um (MMAD) reached the lung, however a substantial<br />
proportion of the compound was found in the nose and the GI<br />
tract. Total respiratory tract deposition was greater with the<br />
larger particle size in all studies. The clearance from the<br />
lung (via the blood and urinary tract) was determined to be<br />
T1/2 = 18 to <strong>20</strong> minutes, and rate of lung clearance was<br />
similar for the two particle sizes and for all species.<br />
The T1/2 for blood was determined in hamster: 3 hours, guinea<br />
pig: 1-3 hours, rabbit: > 6 hours. Hamster showed a large<br />
initial GI deposition whereas for rabbits and guinea pigs the<br />
maximum was reached only 1 hour after exposure.<br />
By six hours after exposure 96% of the total collectable<br />
sulfate was present in the urine. The results of clearance<br />
experiments performed in this study suggested that there was<br />
no specific difference. Apart from the hamsters, the recovery<br />
of 35S in the urine was incomplete.<br />
Test condition: Hamsters (n=8/group) (whole body), guinea pigs<br />
(n=12/group)(whole body fur protected) and rabbits (whole body<br />
and nose only)(number not reported) were studied for<br />
deposition and clearance of inhaled ammonium sulfate (1 - 3<br />
mg/m3; MMAD 0.3 and 0.6 um, 0.05% and 0.5%).<br />
The studies were performed using S35-labeled ammonium<br />
sulfate aerosols with high specific activity. A five minute<br />
exposure time and a short, reproducible time period in which<br />
tissues (blood, lung, nose, urine, GI tract) were obtained for<br />
the first analysis after exposure were necessary to determine<br />
deposition. Clearance was then<br />
measured at 1, 3 and 6 hours after exposures.<br />
Conclusion: Sulfate from the highly water soluble ammonium sulfate was<br />
cleared very rapidly from the body.<br />
Reliability: (2) valid with restrictions<br />
limited documentation<br />
Flag:<br />
Critical study for SIDS endpoint<br />
02-DEC-<strong>20</strong>03 (104)<br />
In Vitro/in vivo:<br />
Type:<br />
Species:<br />
Vehicle:<br />
Route of administration:<br />
In vivo<br />
Absorption<br />
rabbit<br />
physiol. saline<br />
gavage<br />
Method:<br />
GLP:<br />
Test substance:<br />
Result:<br />
142<br />
other: see Test condition<br />
no data<br />
other TS: ammonium sulfate, not<br />
The concentration of ammonium ion in serum had already<br />
increased remarkably 5 min after ingestion (1095 ug/dl) until<br />
it reached 11000 ug/dl. Inorganic sulfate concentration<br />
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