AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
sulfate treated groups.
Test condition: Groups of 6 Wistar rats each were treated by intraperitoneal
injections as follows:
I - 2 mM ammonium sulfate / kg / day for seven days.
II - 3 mM ammonium sulfate / kg, twice daily, for 10 days.
III - 3 mM ammonium sulfate / kg, 4 daily injections, for 10
days.
IV - 6 mM ammonium sulfate / kg / day for 10 days.
V - 6 mM ammonium sulfate / kg, twice daily, for 10 days.
VI - arginine 30 minutes before 10.6 mM ammonium sulfate /
kg for 10 days.
In each group, controls were treated with NaCl injections
instead of ammonium sulfate.
In a separate experiment with 6 Wistar rats, normal enzyme
activities and urea excretion were measured (carbamyl
phosphate synthetase, carbamyl phosphate transferase,
argininosuccinate synthetase, argininosuccinase, arginase).
Test substance: ammonium sulfate
Reliability: (2) valid with restrictions
14-JUN-2004 (156)
Endpoint:
other: enzyme induction
Species:
Syrian hamster
Route of administration: inhalation
No. of animals: 6
Frequency of treatment: 6h/day, 5 days/week and 1, 3, and 10 weeks
Doses: 0.189 mg/m3 (1 and 3 weeks) and 1.35 mg/m3 (1-10
weeks)
Control Group:
other: benzo(a)pyrene (5 mg/week, i.tr.) as positive
control
Result:
Ammonium sulfate inhalation had no effect on lung aryl
hydrocarbon hydroxylase activity. Pulmonary macrophage number
was not affected by ammonium sulfate inhalation.
Significant induction of the enzyme was found with
Benzo(a)pyrene at all analysis periods.
Test condition: This study was designed to investigate levels of aryl
hydrocarbon hydroxylase in hamster lungs. Enzyme activity was
studied after 1,3 and 10 weeks of exposure.
6 animals per group per time period were studied.
Reliability: (2) valid with restrictions
14-JUN-2004 (104)
Endpoint:
other: pulmonary macrophage study
Species:
Syrian hamster
Route of administration: inhalation
No. of animals: 6
Exposure Period:
12 hour(s)
Frequency of treatment: once
Doses:
860 ug/m3
Control Group:
yes
Observation Period:
immediately, 6, 24 hours later
Result:
There was no effect on pulmonary macrophages (number, shape)
in hamsters exposed to 0.86 mg/m3 for 12 hours and a
particle size of 0.3 um.
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