AMMONIUM SULFATE CAS NÂ°: 7783-20-2

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OECD SIDS AMMONIUM SULFATE 5. TOXICITY ID: 7783-20-2 DATE: 18.04.2006 Test condition: This study was designed to investigate pulmonary defense mechanism. Pulmonary macrophage numbers were evaluated. Six sulfate-exposed hamsters were killed immediately after exposure and 6 and 24 hours later. Control animals were studied in the same manner. Reliability: (2) valid with restrictions 11-JUN-2004 (104) Endpoint: Species: Test substance: other: LDL0 cattle other TS: ammonium sulfate Result: Experimental results show that a heifer and a cow were killed by giving them 40 g and 150 g of ammonium sulfate respectively, and further showed that the toxic effect after ingestion of the salt was less than after its subcutaneous injection. Signs of poisoning were severe colic, groaning, staggering, forced rapid breathing, a very marked jugularpulse, and death after violent struggling and bellowing. On post mortem examination in cattle, large hemorrhagic patches on mucous membranes of stomach and intestines with edema and ulceration of intestinal mucous membrane. Liver was enlarged, pale and friable; blood fluid lighter in color than normal; and there were numerous petechiae in skin and throughout carcass. Reliability: (4) not assignable secondary citation 10-APR-2006 (157) Endpoint: Species: Doses: Test substance: other: NOEL cattle 1785 mg/kg other TS: ammonium sulfate Result: Ammonium sulfate did not induce symptoms of any kind in a112 kg calf when given up to 200 g of pure ammonium sulfate as a drench. However, deaths in cattle have been described following contamination of oil-cake with ammonium sulfate. Another case involved deaths of 5 dairy cows which had consumed ammonium sulfate owing to manure drills having been cleaned out on part of pasture. Reliability: (4) not assignable secondary literature 08-DEC-2003 (157) Endpoint: Species: Doses: Test substance: other: LDL0 goat 3500 mg/kg bw other TS: ammonium sulfate Reliability: (4) not assignable secondary literature 08-DEC-2003 (158) Endpoint: 206 other: polioencephalomalacia UNEP PUBLICATIONS
OECD SIDS AMMONIUM SULFATE 5. TOXICITY ID: 7783-20-2 DATE: 18.04.2006 Species: Route of administration: other: cattle and sheep oral Remark: In the latter part of 1991 an unusual neurological disease was recognised on several farms in England. This report describes the case histories and clinical, biochemical and pathological findings in six calves and two lambs aged from two to 44 weeks obtained from five of these farms. Laminar cerebrocortical necrosis and severe bilateral necrosis of the thalamus and/or striatum progressing to cavitation were recognised in the brains. These changes are similar to those of experimental sulphate toxicity. Morbidity rates of 16 to 48% and mortality rates of 0 to 8 % were recorded. The affected animals did not respond to vitamin B1 treatment; the erythrocyte transketolase levels of in-contact cattle and one untreated calf and one untreated lamb were within the normal range. All five farms had recently introduced a proprietary concentrate ration containing ammonium sulfate rather than the normal urinary acidifier ammonium bicarbonate. After this ration was withdrawn no new cases of nervous clinical disease were observed. It is suggested that, in at least some cases, the morphology and topography of lesions may distinguish sulfate induced polioencephalomalacia from that of sporadic thiamine-dependent cerebrocortical necrosis. Reliability: (3) invalid no common test system 10-APR-2006 (159) (160) Endpoint: Species: other: effect of ammonium sulfate on absorption sheep Remark: The experiment was conducted to study the relative effects of sudden doses of urea and ammonium sulfate. The study evaluates urea and ammonium sulfate as separate and combined sources of nonprotein nitrogen in mature ewes and feedlot lambs. Result: Conclusion: The data indicate that ammonia absorption is less rapid when ammonium sulfate is added to the rumen than when an isonitrogenous quantity of urea is administered. In this experiment, 9.3 g of urea nitrogen per 100 lb of bw when given as a drench resulted in two of three ewes dying of ammonia toxicity compared with no toxic symptoms when identical doses of nitrogen were given as ammonium sulfate. The effect of administering urea and ammonium sulfate in combination was similar to a mathematical average of the effects observed when urea and sodium sulfate were administered alone. Reliability: (3) invalid no common test system 10-APR-2006 (161) Endpoint: Neurotoxicity Species: rat Strain: other: Lewis Sex: Route of administration: intrafascicular UNEP PUBLICATIONS 207
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OECD SIDS AMMONIUM SULFATE FOREWORD
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OECD SIDS AMMONIUM SULFATE 10. Comm
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OECD SIDS AMMONIUM SULFATE 1.3 Phys
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OECD SIDS AMMONIUM SULFATE 228 µg/
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OECD SIDS AMMONIUM SULFATE 3.1.3 Ir
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OECD SIDS AMMONIUM SULFATE diarrhoe
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OECD SIDS AMMONIUM SULFATE oral exp
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OECD SIDS AMMONIUM SULFATE Table 3
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OECD SIDS AMMONIUM SULFATE No test
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OECD SIDS AMMONIUM SULFATE Toxicity
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OECD SIDS AMMONIUM SULFATE Table 7
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OECD SIDS AMMONIUM SULFATE 6 REFERE
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OECD SIDS AMMONIUM SULFATE I U C L
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OECD SIDS AMMONIUM SULFATE 1. GENER
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AMMONIUM SULFATE CAS NÂ°: 7783-20-2

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