AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
necropsy was carried out at the end of the test.
The experiments were performed simultaneously in two
different laboratories.
Three male and three female mice were each given a dose of
2000 mg/kg bw. If none of the animals died, further toxicity
tests were not performed and the chemical was regarded as
having an LD50 of greater than 2000 mg/kg bw. If some of the
animals died, a step 2 test was performed at the level of
200 mg/kg bw. If all animals survived in the step 2 test,
the chemical was considered to have an LD50 greater than 200
mg/kg bw. When some of the animals died, the step 3 test
with 20 mg/kg bw was performed. If all the animals died at
this dose level, it meant that he chemical had an LD50 of
less than 20 mg/kg bw. If one or two animals died at the
fixed dose level, the chemical was regarded as having an
LD50 near that dose level, and the approximate LD50 of the
chemical was indicated as ca. 20, 200 or 2000 mg/kg bw.
Reliability: (2) valid with restrictions
limited documentation, no further information on purity
Flag:
Critical study for SIDS endpoint
11-APR-2006 (113)
Type:
Species:
Value:
GLP:
Test substance:
LD50
mouse
= 2450 - 2500 mg/kg bw
no
other TS: ammonium sulfate, two specimens; purity not stated
Test condition: Two specimens of ammonium sulfate were tested: one was
obtained from petrochemical waste products, the other was
obtained from ore wastes of the metallurgical industry.
Reliability: (4) not assignable
documentation insufficient for evaluation
17-MAR-2003 (115)
Type:
Species:
Strain:
Sex:
Vehicle:
Doses:
Value:
Method:
GLP:
Test substance:
Result:
LD50
rabbit
other: Japanese white
no data
physiol. saline
0; 1500 mg/kg bw
= 1500 mg/kg bw
other: see Test Condition
no data
other TS: ammonium sulfate, not further specified
All three substance-treated animals showed similar clinical
symptoms such as mydriasis, and irregular respiration,
beginning at 10-20 minutes after ingestion. Local
convulsions persisted for 5-10 minutes in the face or in the
extremities after starting at 15 to 25 minutes after
ingestion. Soon thereafter they spread to every part of the
body, and the animals repeatedly exhibited opisthotonus,
each lasting for 10-20 seconds. After the general
convulsions, heart rates decreased. 60-70 minutes after
ingestion, all rabbits died from cardiac arrest.
The EEG showed typical signs of hyperammonemia, such as
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