AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
a pair of opposed, collimated, and electrically coupled
scintillation detectors aligned on a common axis on either
side of the thorax. Serial measurements were begun within 2
minutes after inhalation of he tracer aerosol. An additional
retention measurement was performed 24 hours after tracer
exposure.
AEROSOL GENERATION: ammonium sulfate aerosols were generated
from dilute (0.03 N) solutions of the chemical using a
Laskin nebulizer. The output was mixed with filtered room
air which had been temperature and humidity conditioned, and
then conveyed into a mixing chamber containing ports for
aerosol delivery to the five rabbits. Mass concentration of
sulfate was measured in the mixing chamber during each
exposure by sampling with Teflon filters, followed by
sulfate determination using thermometric titration
calorimetry. The size (MMD) of the aerosol was 0.4 um (GSD
1.6).
A series of 10 air sham-control tests (i.e., exposure for
1-hour to temperature and humidity-conditioned air) were
performed on each rabbit prior to any sulfate exposure to
obtain baseline values. Immediately following each exposure,
the rabbit inhaled the tracer aerosol and retention
measurements were begun. Tests at each concentration were
performed twice.
TEST CONCENTRATIONS: 2000 ug/m3 (nominal), 1800 and 2200
(actual)
STATISTICAL ANALYSIS: paired t test.
YEAR OF STUDY: not reported.
Reliability: (2) valid with restrictions
limited documentation
Flag:
Critical study for SIDS endpoint
11-JUN-2004 (118)
Type:
Species:
Doses:
other: cardiopulmonary function
dog
1.1 to 9.5 mg/m3
Remark:
exposure time: 7.5 min to 4 h
Result: Submicron aerosols were administered to groups of 5
anesthetized dogs. Parameters measured included total
respiratory resistance by forced oscillations, static lung
compliance, specific total respiratory conductance and
specific lung compliance. Animals were also exposed to 4.1
mg/m3 for 4 h and additionally functional residual capacity by
helium dilution, systemic and pulmonary arterial blood
pressures, cardiac output by indicator dilution, heart rate,
stroke volume and arterial blood gases were measured at hourly
intervals during the exposure and for two hours following
discontinuation of aerosol administration.
Analysis of variance revealed no statistically significant
differences between sodium chloride and ammonium sulfate
aerosol in any of the parameters measured.
Reliability: (2) valid with restrictions
unusual animal model, but data well documented
Flag:
Critical study for SIDS endpoint
11-APR-2006 (119)
Type:
LC50
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