AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Reliability:
filter sample. Particle size was evaluated gravimetrically
using an Andersen multi-stage sampler. The particle size was
between 2 and 3 um in diameter.
YEAR OF STUDY: not reported.
(4) not assignable
limited documentation, no information on purity and particle
size distribution, only one dose tested.
Flag:
Critical study for SIDS endpoint
12-APR-2006 (120)
Type:
Sub-acute
Species: rat Sex:
Strain: Fischer 344
Route of administration: inhalation
Exposure period:
8 weeks
Frequency of treatment: 4 hours/day on 4 consecutive days per week, for a total
exposure time of 32 days over an 8-week period
Post exposure period: no
Doses:
the tested concentration are given as 20 and 70 ug
sulfate/m3 in the introduction, and 20 and 70 ug
ammoniumsulfate/m3 in the text of the publication
Control Group:
other: purified air
Method:
GLP:
Test substance:
Remark:
Result:
other: see test condition
no data
other TS: ammonium sulfate aerosol, MMAD 0.2 ug, no further
details
F344/N rats (the publication abstract states: Sprague-Dawley)
TOXIC RESPONSE/EFFECT BY DOSE LEVEL:
Mortality, clinical signs: not reported. The treatment had no
effect on respiratory frequency and tidal volume during
exposure (no further details reported).
Body weight: not reported.
Food/Water consumption: not reported.
Gross pathology incidence and severity: not reported
Organ weight changes: not reported
CLINICAL BIOCHEMISTRY FINDINGS:
No exposure related increases in numbers or percentages of
lymphocytes or polymorphonuclear cells were found in the
bronchoalveolar lavage fluid (BAL). The treatment had no
effect on the release of the inflammatory mediators
prostaglandin E2 (PGE2) and leukotriene B4 (LTB4).
Macrophage function:
- 20 µg/m3: macrophages exhibited a significantly depressed
ability to attack antigenic material (Sheep Red Blood Cells)
via Fc receptor-mediated processes. A trend towards increased
production of superoxide by macrophages was observed, but the
changes were not significantly different from the control
values.
- 70 µg/m3: no statistically significant effect on macrophage
function was observed. The production of super-oxide during
respiratory burst activity was significantly depressed.
Permeability of the epithelium:
UNEP PUBLICATIONS 173