AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
hour multiple day exposures to "worst case" ambient
concentrations (0.1-0.3 mg/m3 of ammonium sulfate with a
MMAD of 0.3-0.6 µm and a relative humidity ranging between
40 and 85% in the different experiments).
Test condition: Both healthy, "sensitive" and asthmatic adult men were
exposed to nominal (100 µg/m3) concentrations of ammonium
sulfate, ammonium bisulfate, and sulfuric acid with a mass
median aerodynamic diameter (MMAD) of 0.3 µm and a
geometric standard deviation of approximately 3.
"Sensitive" subjects had been studied previously and had
shown unusually definite reactions in controlled exposures
to ozone. Exposure concentrations and particle size
distributions of the sulfate salts were based on the
highest reported 2-h filter sample of particulate sulfate
in the Los Angeles Basin. Groups of 6 subjects were
typically exposed, 3 at a time. Exposures were performed in
a blind experimental fashion, i.e. subjects were unaware of
their actual aerosol exposure day, with 1 or 2 days of a
"control" exposure to purified air followed by 2 to 3
consecutive days of sulfate aerosol exposure.
To initiate the 2-h protocol, subjects performed baseline
pulmonary function tests on entering the chamber. Subjects
then exercised for the first 15 minutes of each 0.5 h for 2
h, on bicycle ergometers to double, approximately, the
subject´s minute volume of ventilation (comparable to light
outdoor activity). Chamber temperature and relative
humidity were maintained at 31 deg C and 40 per cent
relative humidity which simulated a typical Los Angeles
summer day. Additional exposures to ammonium sulfate were
performed at 85 per cent relative humidity. Lung function
tests were performed before and after exposures and
included FVC, FEV 1.0, maximal mid expiratory flow rate,
total lung capacity, residual volume, single-breath
nitrogen, and total respiratory resistance. Analysis of
subject performance after the exposures to ammonium sulfate
revealed no important differences in response between
normal and sensitive subjects. The measured ammonium
sulfate concentrations were between 0.104 and 0.337 mg/m3,
the MMAD ranged from 0.28 to 0.6 µm.
Reliability:
(2) valid with restrictions
valid with restrictions; no information on purity
Flag:
Critical study for SIDS endpoint
12-APR-2006 (175)
Remark:
A cluster of ten cases of Hodgkin`s disease was identified
within the active workforce of a large chemical
manufacturing firm over a 23-year period. In the total
workforce of 62000 person-years, an expected number of 2.01
cases was calculated, giving a standardized incidence ratio
of 497 (95 % CI 238-915). A nested case-control study was
undertaken with 200 controls. For 11 chemicals (incl.
ammonium sulfate) exposure odds ratios were calculated. No
substance emerged as a likely candidate for explaining the
observed Hodgkin`s disease cluster.
Reliability:
(1) valid without restriction
Flag:
Critical study for SIDS endpoint
20-MAY-2003 (176)
UNEP PUBLICATIONS 213