AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
4. ECOTOXICITY ID: 7783-20-2
DATE: 18.04.2006
Test condition: Three groups of alevins were exposed to ammonium sulfate
solutions for three different lengths of time (21, 40, or 61
days).
In each group, subgroups were exposed to concentrations of
unionized ammonia ranging from 0 to 4 ppb. Test organisms
were exposed at pH 6.3 - 6.5 and 3.7 - 4.8 °C.
Reliability: (2) valid with restrictions
limited documentation
22-JUL-2004 (28)
Species:
other: Channa punctatus
Endpoint:
other: ovarian changes
Exposure period: 6 month
Unit: mg/l Analytical monitoring: no
LOEC: = 500
Method:
GLP:
Test substance:
other: see Test Condition
no
other TS: ammonium sulfate fertilizer, not further specified
Remark:
In comparison to the untreated control, the ovarian growth
was significantly reduced. The gonadosomatic index
(total ovary weight : total body weight x 100) was reduced
and oocytes of ammonium sulfate treated fish were mostly at
stage I of oocyte development and no mature oocytes (stage
IV) occured. Histological examination revealed a number of
oocytes with proteinaceous extra- and intranuclear
"inclusion bodies". These oocytes degenerated. The author
concluded that ammonium sulfate is affecting ovarian growth,
however no mode of action could be deduced from this study.
Result:
No external manifestation of toxicity was observed, but
ovarian growth was significantly reduced (gonadosomatic
index of 1.18 vs 1.92 for the controls).
Test condition: Forty adult C. punctatus were caught in the wild, acclimated
to laboratory conditions and split up between two 30-liter
glass aquaria containing water at pH 7.2. One group was
exposed to 500 ppm ammonium sulfate, and the other group
served as the control. The experiment ran from the first
week of January when the ovary was in the resting phase, and
ended the last week of June when control fish exhibited
spawning phase ovaries.
Reliability: (2) valid with restrictions
10-MAR-2003 (91)
Species:
other: Channa punctatus
Exposure period: 6 month
Remark:
A dose-dependend effect on liver and thyroid has was
reported when adult fish were exposed to 100 ppm ("safe
concentration") or 500 ppm ("sublethal concentration") of
ammonium sulfate for 6 month. Hepatocytes revealed initial
hypertrophy followed by exhaustion as evidenced by degranulation,
nuclear pyknosis and focal necrosis. Thyroid
follicles exhibited various degrees of hypertrophy,
hyperplasia, hyperemia and reduction in colloid content.
The authors concluded that ammonium sulfate is causing
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