AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
convulsion when ammonium sulfate was injected.
Reliability: (2) valid with restrictions
limited documentation, no further information on purity
18-NOV-2003 (109)
Type:
Distribution
Remark:
In aqueous environments, such as the body the ammonium sulfate
is completely dissociated into the ammonium (NH4+) and the
sulfate (SO42-) ions. At physiological pH in aqueous media,
the ammonium ion is in equilibrium with un-ionized ammonia,
according to the following equation:
NH4+ + H2O --- NH3 + H3O+
The ammonium ion serves a major role in the maintenance of the
acid-base balance. In the normal pH range of blood, the NH4+ /
NH3 is about 100.
Reliability: (2) valid with restrictions
reliable review
10-APR-2006 (11)
Type:
Absorption
Remark: Absorption of sulfate depends on the amount ingested. 30-44%
of sulfate was excreted in the 24-h urine after oral
administration of magnesium or sodium sulfate (5.4 g sulfate)
in volunteers. At high sulfate doses that exceed intestinal
absorption, sulfate is excreted in feces. Intestinal sulfate
may bind water into the lumen and cause diarrhoea in high
doses. Sulfate is a normal constituent of human blood and does
not accumulate in tissues. Sulfate levels are regulated by the
kidney through a reabsorption mechanism. Sulfate is usually
eliminated by renal excretion. It has also an important role
in the detoxification of various endogenous and exogenous
compounds, as it may combine with these to form soluble
sulfate esters that are excreted in the urine.
Reliability: (2) valid with restrictions
reliable review
10-APR-2006 (110)
5.1 Acute Toxicity
5.1.1 Acute Oral Toxicity
Type:
Species:
Strain:
Sex:
Vehicle:
Doses:
Value:
LD50
rat
no data
male/female
other: water (test substance was applied as a 30 % aqueous
solution)
2500, 3200, 4000, 5000, 6400 mg/kg bw
= 4250 mg/kg bw
Method:
other: see Test Condition
Year: 1969
GLP:
no
UNEP PUBLICATIONS 145