AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Flag:
Critical study for SIDS endpoint
14-JUN-2004 (177)
Remark:
Total nuisance dust air concentrations were measured during
bagging and bulk loading of fertilizer, ammonium sulfate
and
ammonium phosphate. Four samples showed nuisance dust
concentrations ranging from none to 0.38 mg/m3. At a
follow-up survey, six environmental air samples collected
ranged from 2.55 to 11.1 mg/m3 (only one sample exceeded
10.0 mg/m3). Recommendations were made to reduce exposure
to
nuisance dust and improve dust control.
Reliability:
(2) valid with restrictions
limited documentation; no follow-up results (i.e. after
implementation of recommended measures) available.
20-MAY-2003 (178)
Remark:
Ammonium sulfate elicited significant changes in pulmonary
flow resistance (34 % decrease) and dynamic lung compliance
(17 % decrease) in human volunteers. These changes appeared
late in exposure (120 minutes and 90 minutes, resp.) and
were partially reversed after 30 minutes recovery.
Method: 4 healthy adult non-smoking human volunteers were
exposed to 1 mg/m3 ammonium sulfate (droplet aerosol, MMD
0.71 µm GSD 1.8, rel. humidity > 80 %) Exposure consisted
of a 30-40 min. baseline period of room air followed by two
hours of exposure (oral breathing) and a subsequent 45 min.
recovery period. Pulmonary function was measured every 30
min.
Reliability:
(2) valid with restrictions
valid with restrictions; substance purity not given
Flag:
Critical study for SIDS endpoint
10-APR-2006 (122)
Type of experience: other: case-control study
Method:
A self-administered questionnaire was used to obtain
information on past occupation and smoking status. The
following chemical exposures were listed in the
questionnaire for a yes/no response: organic solvent, lead,
cadmium, nickel, chromium, asbestos, acrylonitrile,
arsenic,
and beryllium (NOTE: ammonium sulfate was NOT included). A
free format question was also included in the questionnaire
for obtaining information on other exposures.
The past history of occupational exposures, which was
obtained by yes/no questions from selected substances as
well as by the free question was classified into 6
categories: inorganic acid/base, asbestos, dust excluding
asbestos, organic chemicals, metals, and others, and
relative risks were estimated by a conditional logistic
model controlling for smoking and concomitant exposures.
The
workers exposed to inorganic acid/base showed a significant
increase in risk at the 5% level (RR = 4.03). The chemicals
classified into this category were sulfuric acid,
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