AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
MTD), the interval between termination of exposure and
examination was too long.
10-APR-2006 (104) (137)
Species: other: SHE Cells Sex:
Result:
negative
Method:
other: cell transformation test
Remark:
no further details available. Secondary citation.
Reliability: (4) not assignable
secondary citation
19-APR-2003 (148)
5.8.1 Toxicity to Fertility
Type:
other
Remark:
10-APR-2006
For the endpoint fertility studies with ammonium sulfate were
not available.
As Ammonium sulfate dissociated in biological systems studies
with other ammonium and sulfate salts can be used to cover
these endpoint: A screening study for
reproductive/developmental according OECD TG 422 screening
study was reported with diammonium phosphate as analogue
substance which forms ammonium ions in aqueous solutions.
Fully valid fertility studies with analogue compounds
containing sulfate ions are however lacking. Two limited
studies with sodium sulfate can be used for assessment of
fertility.
Type:
One generation study
Species:
mouse
Strain:
ICR
Route of administration: drinking water
Exposure Period:
from one week prior to breeding until study end (day
21 of second parity)
Frequency of treatment: continuously
Premating Exposure Period
male:
no treatment (tap water ad lib)
female:
1 week
Doses:
625, 1250, 2500 or 5000 mg sulfate/L in drinking
water
Control Group:
yes, concurrent vehicle
NOAEL Parental: = 5000 mg/l
Method:
other: see Test Condition
Year: 1988
GLP:
no data
Test substance: other TS: sodium sulfate, reagent grade
Result:
Control mice, receiving only distilled water, consumed
significantly less than mice receiving sulfate treatments,
and sodium-control mice drank significantly more water than
UNEP PUBLICATIONS 197