AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
significant effect on gestation gain, number of pigs per<br />
litter at birth (total and live) or average pig and litter<br />
birth weights. Lactation gain, number of pigs at 28 days and<br />
average pig and litter weights at 28 days were not<br />
significantly affected by sulfates in water during<br />
lactation. Slightly less saline water was consumed during<br />
gestation. However, in lactation, water consumption<br />
increased (p > 0.05) as total dissolved solids increased.<br />
The general condition and performance of the pigs during the<br />
28-day nursing period were similar among groups. No<br />
significant differences occurred at 28 days in average daily<br />
gain or feed to gain ratio among weaned pigs that received<br />
the control water and those that consumed sulfate added<br />
water.<br />
Test condition: 31 sows and 27 gilts were divided into three groups that<br />
received either tap water (3<strong>20</strong> mg sulfate/L) or water with<br />
sodium sulfate added at 1790 or 3298 mg/L from pre-breeding<br />
day 30 through lactation day 28. Sulfate concentration was<br />
determined weekly.<br />
Reliability: (3) invalid<br />
limited documentation, no approved test system<br />
11-JUN-<strong>20</strong>04 (154)<br />
Remark: No effects to the offsprings were observed in the OECD TG 422<br />
screening study with diammonium phosphate. More information<br />
see 5.8.1.<br />
05-FEB-<strong>20</strong>04<br />
5.8.3 Toxicity to Reproduction, Other Studies<br />
5.9 Specific Investigations<br />
Endpoint:<br />
other: Influence on enzyme activities<br />
Result:<br />
The addition of 125-1000 mM ammonium sulfate to rat hepatic<br />
washed microsomal preparations markedly stimulated the rate<br />
of in vitro metabolism of the hepatocarcinogen<br />
dimethylnitrosamine. Ammonium sulfate can reversibly modify<br />
conformation of microsomal membranes in such manner as to<br />
increase or decrease microsomal enzyme activities.<br />
Reliability: (1) valid without restriction<br />
18-NOV-<strong>20</strong>03 (155)<br />
Endpoint:<br />
Species:<br />
other: metabolism, influence on enzyme activities<br />
rat<br />
Result:<br />
<strong>20</strong>4<br />
Intraperitoneal injections of sublethal doses of ammonium<br />
sulfate had no effect on five enzymes of the urea cycle nor<br />
on the activity of aspartate transcarbamylase. Significant<br />
reductions in body weights were seen in most ammonium<br />
UNEP PUBLICATIONS
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