AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
EXPOSURE TO TEST SUBSTANCE:<br />
The animals were fed CRF-1 powder diet containing<br />
concentrations of 0, 0.38, 0.75, 1.5, and 3.0% of ammonium<br />
sulfate. The dose levels were set on the basis of results<br />
from a previous 2-week study with a dose level of 5% (no<br />
further details reported).<br />
ORGANS WEIGHED:<br />
At necropsy, the following organs were weighed and absolute<br />
and relative organ weights determined:<br />
males: brain,lung,heart,spleen,liver,adrenal,kidney,testis.<br />
females: brain,lung,heart,spleen,liver,adrenal,kidney.<br />
ORGANS EXAMINED HISTOPATHOLOGICALLY:<br />
males: brain, lung, heart, spleen, liver, adrenal, kidney,<br />
testis.<br />
Reliability: (2) valid with restrictions<br />
ovaries not weighed and examined<br />
Flag:<br />
Critical study for SIDS endpoint<br />
10-APR-<strong>20</strong>06 (134)<br />
5.8.2 Developmental Toxicity/Teratogenicity<br />
Species: other Sex:<br />
Remark:<br />
10-APR-<strong>20</strong>06<br />
For the endpoint developmental toxicity studies with ammonium<br />
sulfate were not available.<br />
As Ammonium sulfate dissociated in biological systems studies<br />
with other ammonium and sulfate salts can be used to cover<br />
these endpoints: A screening study for<br />
reproductive/developmental according OECD TG 422 screening<br />
study was reported with diammonium phosphate as analogue<br />
substance which forms ammonium ions in aqueous solutions.<br />
Fully valid developmental studies with analogue compounds<br />
containing sulfate ions are however lacking. Two limited<br />
studies with sodium sulfate can be used for assessment of<br />
fertility and developmental toxicity, however, in non of these<br />
studies have the fetuses been examined histologically.<br />
Species: mouse Sex: female<br />
Strain:<br />
ICR<br />
Route of administration: gavage<br />
Exposure period: gestation day 8 through 12<br />
Frequency of treatment: daily<br />
Doses:<br />
2800 mg/kg bw/day<br />
Control Group:<br />
yes, concurrent vehicle<br />
NOAEL Maternal Toxity: < 2800 mg/kg bw<br />
NOAEL Teratogenicity: = 2800 mg/kg bw<br />
Method:<br />
GLP:<br />
Test substance:<br />
Result:<br />
<strong>20</strong>2<br />
other: see Test Condition<br />
no data<br />
other TS: sodium sulfate<br />
No evidence of maternal toxicity (mortality, body weight<br />
gain), or increased resorption rate was found. The chemical<br />
had no influence on pup survival, and no adverse developmental<br />
UNEP PUBLICATIONS
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