AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
Inhalation of ammonium sulfate did not have any effect on body<br />
weights.<br />
The incidence of respiratory cancer was 1.4% in unexposed<br />
controls, 2.9% in hamsters exposed to ammonium sulfate<br />
alone, 14.4% in those given only B(a)P injections and 11.8%<br />
in those given B(a)P injections and exposed to ammonium<br />
sulfate. The increased incidence of cancer with B(a)P was<br />
statistically significant (p < 0.005). The incidence of all<br />
cancer was 5.9% in unexposed controls, 4.0% in hamsters<br />
exposed to ammonium sulfate alone, 34.6% in those given only<br />
B(a)P injections and 27.9% in those given B(a)P injections<br />
and exposed to ammonium sulfate.<br />
Test condition:<br />
The B(a)P alone group had increased mortality in the first<br />
months after exposure and an increased incidence in<br />
respiratory tract malignancy when compared with the<br />
BaP/ammonium sulfate group. Histologically, the malignancies<br />
seen in the respiratory tract were poorly differentiated<br />
squamous carcinomas and undifferentiated large cell<br />
malignancies.<br />
The study was designed as co-carcinogenicity<br />
experiment.<br />
Approximately 10-weeks old animals were divided into the<br />
following groups (80 animals/group).<br />
- Benzo(a)pyrene (BaP) alone,<br />
- ammonium sulfate alone,<br />
- BaP/ammonium sulfate together,<br />
- and a control group.<br />
Hamsters receiving BaP alone were given 5-mg doses by<br />
intratracheal injections once a week for 15 weeks.<br />
The ammonium sulfate group was exposed for 6 hours/day, 5<br />
days/week for 15 weeks to an average concentration of 186.6<br />
ug/m3 sulfate (nominal concentration: <strong>20</strong>0 ug/m3, particle<br />
size: 0.3um -0.6 um MMAD).<br />
The concentration was chosen as a conservative extrapolation<br />
of environmentally relevant levels.<br />
The BaP/ammonium sulfate group was simultaneously exposed to<br />
197.6 ug/m3 for 6 hours/day, 5 days/week, 15 weeks.<br />
The examination of all animals was performed two years later.<br />
Conclusion:<br />
Reliability:<br />
196<br />
The study was repeated with the same protocol.<br />
At necropsy gross observations were made on all internal<br />
organs, including the brain, nasal structures and larynx.<br />
Histologic sections of the respiratory tract (nose, larynx,<br />
bronchi, all lobes of the lung) were prepared and<br />
hematoxylin and eosin stained slides were evaluated.<br />
The study showed that ammonium sulfate inhalation had no<br />
effect on the development of pulmonary cancer and no effect<br />
on the development of other significant pulmonary diseases<br />
in hamsters. Ammonium sulfate has not a co-carcinogenic<br />
effect.<br />
(3) invalid<br />
co-carcinogenicity study, time and concentration insufficient<br />
for valid negative carcinogenicity study, only one dose (no<br />
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