AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
history. Lung volumes in spontaneously breathing animals
were determined by connecting a syringe to the airway
opening, evacuating the lungs to residual volume, then
inflating the lungs to total lung capacity. During these
maneuvers, volume excursions and transpulmonary pressure
were recorded. Residual volume was determined by inert gas
dilution, using 0.5% neon in air as the test gas.
Single-breath carbon monoxide diffusion capacity of the lung
was determined by a modification of the technique of
Takezawa et al (1980, J.App.Physiol. 48, 1052-1059). Following
these measurements, animals were paralyzed by intramuscular
injections of succinyl choline chloride and artificially
ventilated with a rodent respirator. Quasistatic compliance
and single-breath N2 washout maneuvers were performed by
inflating the lungs with air or O2, respectively at flow rates
of 2.5 mL/sec to twice the total lung capacity, and then
deflating the lungs, at the same flow rate, to residual
volume. Functional residual capacity (the volume of gas in the
lungs following normal
passive exhalation) was measured in paralyzed animals using
the inert gas dilution technique used to measure residual
volumes in spontaneously breathing animals.
Statistical Method: analysis of variance.
Year of study: not reported.
Conclusion: The pattern of lung volume changes observed in ammonium
sulfate exposed rats (increased residual volume and
functional residual capacity, with no significant change in
vital capacity) suggest that ammonium sulfate exposure
resulted in mild pulmonary emphysema or slight exacerbation
of elastase induced emphysema.
Reliability: (4) not assignable
limited documentation, no further information on purity, only
one dose tested.
10-APR-2006 (132)
Type:
Sub-acute
Species: rat Sex: male
Route of administration: inhalation
Exposure period:
8h/day
Frequency of treatment: 3 days
Doses:
1000-1200 mg/m3, particle size 2-3um
Method:
GLP:
Test substance:
other: see test conditions
no data
other TS: ammonium sulfate, not further specified
Result:
None of the rats died during the exposures. No gross
toxicological effects were noted (no further details
reported).
Test condition: A group of 6 male rats was exposed(whole body) 8 h/day for 3
consecutive days to a concentration of 1000-1200 mg/m3
(maximum attainable concentration).
Ammonium sulfate aerosol was generated from an aqueous
solution with Retec nebulizers and dried by mixing with dry
air and passing it through a heated glass tube. Ammonium
sulfate concentration was determined by collecting the
aerosol on a glass fiber filter at a flow rate of 2 L/min
for 15 minutes and weighing the filter. Accuracy of the
method was periodically checked by chemical analysis of the
172
UNEP PUBLICATIONS