AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
animals, while two of the four demonstrated a more persistent
clearance. These exposure levels produced no measurable change
in resistance, compliance or regional deposition. Exposure to
(NH4)SO4 up to ca. 2000 ug/m3 had no measurable effect upon
resistance, compliance, regional deposition or mucocilary
clearance.
Test condition: The effects of one-hour inhalation exposure 0.3-0.6um H2SO4
and (NH4)2SO4 aerosols were studied in terms of alterations in
pulmonary flow resistance and dynamic compliance, and changes
in the regional deposition and tracheobronchial mucociliary
clearance.
respiratory mechanics
4 Donkeys were exposed with a catheter to H2SO4 aerosol
(0.07-1.4 mg/m3) or to ammonium sulfate aerosols (0.3-3.1
mg/m3) for 1 hour/week for about 1 year.
The median aerodynamic diameter (MAD) for both aerosols was
0.3 to 0.6 um and the standard geometric deviation 1.5 um.
prior the sulfate exposure, baseline control values for
pulmonary resistance (R1) and dynamic compliance (Cdyn) were
obtained by talking at least three successive sets of ten
measurements, this allowed determination of spontaneous
variability of individual measurements.
The first post-exposure measurements were obtained within one
minute of the end of the sulfate aerosol exposure period.
To determine any effects upon mechanics due solely to
breathing from the sulfate generation unit, R1 and Cdyn were
measured following five sham exposures of each donkey. These
sham exposures had no effect upon R1 or Cdyn. regional
deposition and clearance.
A series of eleven control tests was performed on each animal
to determine baseline values for percentage 24 h-clearance,
bronchial clearance half-time, and tracheal transport rate.
Additional control tests were performed on the day preceding a
sulfate exposure, and occasionally on the day following.
To determine the effect of sulfate exposure upon regional
deposition, each donkey was exposed to sulfate followed,
within a minute, by inhalation of the radioactive tagged
ferric oxide aerosol.
The exposure were also performed in which ferric oxide was
inhaled prior to the one-hour exposure to sulfate.
Three sham exposure controls using each of the above two
protocols were performed on each donkey, these had no effect
upon regional deposition or clearance.
Conclusion: Exposure to up to 3.1 mg/m3 (1 hour/week, 1 year) had no
effect on pulmonary defense mechanisms in donkeys.
Reliability: (3) invalid
no common test system
10-APR-2006 (123)
5.5 Genetic Toxicity 'in Vitro'
Type:
Ames test
System of testing: Salmonella typhimurium TA1535 TA100 TA1537 TA98
Concentration:
0, 20, 100, 500, 2500 and 5000 ug/plate
Cytotoxic Concentration: not cytotoxic up to and including the highest tested
concentration level
Metabolic activation: with and without
Result:
negative
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