AMMONIUM SULFATE CAS NÂ°: 7783-20-2

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OECD SIDS AMMONIUM SULFATE 5. TOXICITY ID: 7783-20-2 DATE: 18.04.2006 d), 2.1-3.0 mg SO4/m3: 52/96 (54.2%*, mean survival time:9.2 d), 3.1-4.0 mg SO4/m3: 47/144 (32.6%, mean survival time:11.2 d), 5.3 mg (NH4)2SO4/m3: 46/110 (41.8%, mean survival time:10.3 d). * sign. difference from control, determined by chi-square test, p < 0.05 Test condition: The relative toxicities of zinc sulfate and ammonium sulfate were assessed using a streptococcal model. Mice inhaled varying concentrations of the sulfates for 3 hours and immediately thereafter were challenged with airborne streptococcus. Between 48 and 144 mice were used per treatment group (ammonium sulfate; 588 mice were used in the control group). For the experiments with zinc sulfate, between 278 and 599 mice were used per group and 1689 mice were used as controls. Statistical methods: chi-square test for mortalities, Student`s t-test for mean survival time, significance levels at p
OECD SIDS AMMONIUM SULFATE 5. TOXICITY ID: 7783-20-2 DATE: 18.04.2006 a pair of opposed, collimated, and electrically coupled scintillation detectors aligned on a common axis on either side of the thorax. Serial measurements were begun within 2 minutes after inhalation of he tracer aerosol. An additional retention measurement was performed 24 hours after tracer exposure. AEROSOL GENERATION: ammonium sulfate aerosols were generated from dilute (0.03 N) solutions of the chemical using a Laskin nebulizer. The output was mixed with filtered room air which had been temperature and humidity conditioned, and then conveyed into a mixing chamber containing ports for aerosol delivery to the five rabbits. Mass concentration of sulfate was measured in the mixing chamber during each exposure by sampling with Teflon filters, followed by sulfate determination using thermometric titration calorimetry. The size (MMD) of the aerosol was 0.4 um (GSD 1.6). A series of 10 air sham-control tests (i.e., exposure for 1-hour to temperature and humidity-conditioned air) were performed on each rabbit prior to any sulfate exposure to obtain baseline values. Immediately following each exposure, the rabbit inhaled the tracer aerosol and retention measurements were begun. Tests at each concentration were performed twice. TEST CONCENTRATIONS: 2000 ug/m3 (nominal), 1800 and 2200 (actual) STATISTICAL ANALYSIS: paired t test. YEAR OF STUDY: not reported. Reliability: (2) valid with restrictions limited documentation Flag: Critical study for SIDS endpoint 11-JUN-2004 (118) Type: Species: Doses: other: cardiopulmonary function dog 1.1 to 9.5 mg/m3 Remark: exposure time: 7.5 min to 4 h Result: Submicron aerosols were administered to groups of 5 anesthetized dogs. Parameters measured included total respiratory resistance by forced oscillations, static lung compliance, specific total respiratory conductance and specific lung compliance. Animals were also exposed to 4.1 mg/m3 for 4 h and additionally functional residual capacity by helium dilution, systemic and pulmonary arterial blood pressures, cardiac output by indicator dilution, heart rate, stroke volume and arterial blood gases were measured at hourly intervals during the exposure and for two hours following discontinuation of aerosol administration. Analysis of variance revealed no statistically significant differences between sodium chloride and ammonium sulfate aerosol in any of the parameters measured. Reliability: (2) valid with restrictions unusual animal model, but data well documented Flag: Critical study for SIDS endpoint 11-APR-2006 (119) Type: LC50 UNEP PUBLICATIONS 153
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OECD SIDS AMMONIUM SULFATE FOREWORD
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OECD SIDS AMMONIUM SULFATE 10. Comm
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OECD SIDS AMMONIUM SULFATE Consumer
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OECD SIDS AMMONIUM SULFATE 1.3 Phys
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OECD SIDS AMMONIUM SULFATE 228 µg/
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OECD SIDS AMMONIUM SULFATE 3.1.3 Ir
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OECD SIDS AMMONIUM SULFATE diarrhoe
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OECD SIDS AMMONIUM SULFATE oral exp
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OECD SIDS AMMONIUM SULFATE Toxicity
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OECD SIDS AMMONIUM SULFATE I U C L
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OECD SIDS AMMONIUM SULFATE 1. GENER
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OECD SIDS AMMONIUM SULFATE 2. PHYSI
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OECD SIDS AMMONIUM SULFATE 3. ENVIR
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AMMONIUM SULFATE CAS NÂ°: 7783-20-2

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