AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Reliability: (2) valid with restrictions
no common test system
10-APR-2006 (126)
5.2 Corrosiveness and Irritation
5.2.1 Skin Irritation
Species:
rabbit
Concentration: 80 %
Exposure:
Occlusive
Vehicle:
water
Result:
not irritating
Method:
other: see Test Condition
Year: 1969
GLP:
no
Test substance: other TS: as prescribed by 1.1 - 1.4, "chemically pure"
Result:
Barely visible skin erythema (equivalent to a Draize score
of 0) was noted at 24 hours after exposure when test
substance was applied for 5 minutes, 15 minutes or 20 hours.
No effects were noted at 8 days after the end of the
exposure or after exposure to the test substance for only 1
minute. Neither scaling nor edema were noted at any
observation time.
No mortality occurred and there were no clinical signs of
toxicity observed.
Test condition: According to "Description of methods used in BASF acute
toxicity and skin/eye irritation studies before pertinent
OECD/EU test guidelines were in place" (BASF AG, 2002)
TEST ANIMALS: Rabbits, White Vienna strain, 2 animals. Each
animal was treated with the test substance as 80% aqueous
preparation for 1 minute, 5 minutes, 15 minutes and 20
hours.
The test substance was applied under occlusive dressing to
the back skin of the animals.
OBSERVATIONS: the treated skin was evaluated for irritant
effects at the end of the exposure, i.e. at 1 minute, 5
minutes, 15 minutes and 20 hours and at 24 hours and 8 days
after start of the study.
Reliability: (2) valid with restrictions
limited documentation, application time not according to OECD
TG 404
Flag:
Critical study for SIDS endpoint
08-DEC-2003 (111)
Species:
Concentration:
Exposure:
Result:
rabbit
undiluted
Semiocclusive
not irritating
Method:
other: see Test Condition
Year: 1968
GLP:
no
Test substance: other TS: ammonium sulfate, about 0.1% water content,
UNEP PUBLICATIONS 161