AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Positive controls:
- 2-acetylaminofluorene and dimethylnitrosamine for
experiments with S-9 mix
- ethyl methanesulfonate, 2-nitrofluorene, and quinacrine
mustard for experiments without metabolic activation.
Evaluation criteria: not reported.
Reliability: (2) valid with restrictions
limited documentation, no further information on purity
Flag:
Critical study for SIDS endpoint
10-APR-2006 (139)
Type:
Yeast gene mutation assay
System of testing: Saccharomyces cerevisiae D4
Concentration:
25,000 and 50,000 ppm (2.5 and 5%; 25, 50 mg/mL)
Cytotoxic Concentration: not cytotoxic
Metabolic activation: with and without
Result:
negative
Method:
other: standard suspension test.
Year: 1975
GLP:
no
Test substance: other TS: ammonium sulfate granular food grade
Remark:
The ade locus appeared not to respond to the positive
control. No reason for the lack of response was evident.
The try locus appeared normal and the data was considered
to be acceptable.
Test condition: Solvent: Saline.
The tissue homogenates and 9,000 g supernatants were
prepared from tissues of the following species: mouse, ICR
random bred adult males; rat, Sprague-Dawley adult males;
primate, Macaca mulatta, adult males.
positive controls:
activation assay:
Dimethylnitrosamine, 2-acetylaminofluorene
nonactivation assay:
ethyl methanesulfonate
2-nitrofluorene
quinacrine mustard
Reliability: (2) valid with restrictions
limited documentation, no further information on purity
Flag:
Critical study for SIDS endpoint
05-NOV-2003 (139)
Type:
Cytogenetic assay
System of testing: human lymphocytes
Concentration:
3.2 M (423 mg/mL)
Cytotoxic Concentration: cytotoxicity not reported
Metabolic activation: without
Result:
negative
Method:
GLP:
Test substance:
Result:
186
other: see Test Condition
no data
other TS: ammonium sulfate, analytical grade
Effects of the restriction endonuclease Alu I on chromosomes
were more pronounced when the cells were treated
additionally with ammonium sulfate.
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