AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
weighed between 6 and 14 mg (mean value 9.2 mg). Similar or
higher increases in parathyroid weight were also found with
all other chemicals tested in this study (ammonium
hydroxide, carbonate, chloride, hydrophosphate, acetate,
lactate, calcium chloride, hydrochloric acid, lactic and
acetic acids, sodium ammonium phosphate, and sodium
dihydrogen phosphate). The author considers this effect to
be caused by metabolic acidosis that was induced by the
various chemicals (though no experimental data relating to
the latter were provided in the publication).
Test condition: 10 females were treated with 100-200 mg ammonium sulfate /
kg bw, dissolved in 100-150 cm3 drinking water every second
day. The dose was gradually increased over the experimental
period of 5-16 months (no further details given). Each 4th
week was scheduled as a recovery period without treatment.
Reliability: (4) not assignable
documentation insufficient for assessment
19-JUL-2004 (136)
Type:
Sub-chronic
Species: Syrian hamster Sex: male
Route of administration: inhalation
Exposure period:
15 weeks
Frequency of treatment: 6 hours/day, 5 days/week
Doses:
186.6 ug/m3 (analytical) (200 ug/m3 , nominal)
Control Group:
other: BaP
Method:
other: see Test Condition
Year: 1978
GLP:
no
Test substance: other TS: ammonium sulfate, no further specified
Remark:
Result:
The study evaluated the influence of ammonium sulfate as a
cofactor in carcinogenesis studies employing benzo(a)pyrene as
the prime agent. Additional information concerning influence
on a metabolic enzyme (arylhydroxylase) and the body`s
absorption and excretion of sulfate was also included (cf
IUCLID section on toxicokinetics). NOTE: wrong units (mg
instead of ug) were used in some parts of the publication by
Godleski et al., 1984.
Inhaled ammonium sulfate did not increase the incidence or
severity of pneumonitis or pulmonary fibrosis in the hamster.
This inhalation did increase the incidence of emphysema as
examined microscopically but not the severity. The increase in
emphysema incidence was not statistically significant (9.0 vs
15.2%, EPA 1978). Another publication of this study described
an increase in emphysema incidence, which is however of
doubtful statistical significance. It was based on only 80
animals per group (8.6 vs 16.1%, Godleski, 1984). Due to the
higher number of animals used the EPA results are more
reliable and 0.2 mg/ammonium sulfate/m3 cannot be regarded as
a LOAEL. However it seems not acceptable to take 0.2 mg/m3 as
the NOAEL from this study because the animals were not
examined immediately after exposure but only after 2 years.
Test condition: 80 approximately 10-week old animals were exposed for 6
hours/day, 5 days/week for 15 weeks at an average
concentration of 186.6 ug/m3 (nominal concentration 200
ug/m3).
After 2 years, histological sections of the respiratory tract
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