AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
AMMONIUM SULFATE CAS N°: 7783-20-2
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OECD SIDS<br />
<strong>AMMONIUM</strong> <strong>SULFATE</strong><br />
5. TOXICITY ID: <strong>7783</strong>-<strong>20</strong>-2<br />
DATE: 18.04.<strong>20</strong>06<br />
susceptibility to group streptococcal aerosol infection<br />
relative to filtered air controls. Pulmonary bactericidal<br />
activity by alveolar macrophages was significantly enhanced in<br />
the lungs of mice exposed to the mixture relative to those<br />
inhaling filtered air or O3 alone.<br />
The mixture caused alterations in several host defense<br />
mechanism.<br />
Reliability: (3) invalid<br />
mixture exposure, exposure to streptococcal aerosol infection,<br />
10-APR-<strong>20</strong>06 (171)<br />
Endpoint:<br />
other: inhalation mix-exposure<br />
Species:<br />
rat<br />
Strain: Sprague-Dawley Sex: male/female<br />
Route of administration: inhalation<br />
Exposure Period:<br />
56 day(s)<br />
Frequency of treatment: 4h/day and 4days/week<br />
Reliability: (3) invalid<br />
mix-exposure: Ammonium sulfate, ammonium nitrate and road<br />
dust.<br />
12-APR-<strong>20</strong>06 (133) (172)<br />
Endpoint:<br />
Species:<br />
Doses:<br />
other: cardiopulmonary function<br />
sheep<br />
1,1 mg/m3<br />
Result: In conscious sheep, tracheal mucous velocity was altered by <strong>20</strong><br />
min exposure to submicron aerosols (1,1 mg/m3) of the ammonium<br />
sulfate. Tracheal mucous velocity was measured by following<br />
the motion of <strong>20</strong>-30 radiopaque Teflon disks deposited within<br />
the trachea.<br />
Reliability: (2) valid with restrictions<br />
unusual animal model, data well documented<br />
Flag:<br />
Critical study for SIDS endpoint<br />
10-APR-<strong>20</strong>06 (119)<br />
5.10 Exposure Experience<br />
Result:<br />
The acute exposure of asthmatic volunteers to 1000 ug/m3<br />
ammonium sulfate (ACS certified grade) did no significantly<br />
decrease specific airway conductance and forced expiratory<br />
volume in one second. Flow rates were not altered.<br />
Test condition: 10 asthmatic subjects to 1,000 ug/m3 ammonium sulfate for<br />
16 minutes (aerodynamic diameter: 0.6 to 1 um). NaCl<br />
aerosol of similar characteristics, administered by<br />
double-blind randomization, served as control.<br />
Reliability:<br />
(1) valid without restriction<br />
Flag:<br />
Critical study for SIDS endpoint<br />
06-APR-<strong>20</strong>06 (173)<br />
Type of experience: other: controlled study<br />
Result:<br />
Exposure to ammonium sulfate showed no significant effects<br />
on any pulmonary function measurements.<br />
UNEP PUBLICATIONS 211
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