AMMONIUM SULFATE CAS N°: 7783-20-2

OECD SIDS
AMMONIUM SULFATE
5. TOXICITY ID: 7783-20-2
DATE: 18.04.2006
Test substance:
other TS: as prescribed by 1.1 - 1.4, "chemically pure"
Result:
The LD50 was determined to be 4250 mg/kg bw (95% confidence
limits: 3788-4769).
Mortality and time of death(s) per dose group:
6400 mg/kg bw: 12 died within the first hour, 2 within 24
hours, 4 within 48 hours; in total, 18/20 died within 7
days.
5000 mg/kg bw: 8 died within the first hour, 1 within 24
hours, 1 within 48 hours; in total 11/20 died within 7 days.
4000 mg/kg bw: 7 died within 24 hours, and 2 within 48
hours; in total, 9/20 died within 7 days.
3200 mg/kg bw: 1 animal died within the first hour, 1 within
24 hours, 2 within 48 hours; in total, 4/20 died within 7
days.
2500 mg/kg bw: no deaths occurred.
Clinical signs observed were:
4000-6400 mg/kg bw: immediately after application
staggering, abdominal and lateral position, partly dorsal
position, apathy, laboured and irregular breathing. On the
next day, secretion out of eyes and mouth, reddened eyes and
nose. In the post-exposure observation days the animals were
without clinical symptoms.
3200 mg/kg bw: No symptoms on the application day. The next
day, reddened eyes and nose, and irregular breathing were
noted. Later without clinical signs.
2500 mg/kg bw: No clinical signs noted.
At necropsy, fluid in the thoracic cavity was observed in a
few animals. In three animals, the stomach was filled with
liquid, and bloody mouth and forelegs were noted. No
pathological findings were noted with regard to the inner
organs.
Test condition: According to "Description of methods used in BASF acute
toxicity and skin/eye irritation studies before pertinent
OECD/EU test guidelines were in place" (BASF AG, 2002)
TEST ANIMALS: Rats of the Gassner strain, mean weight at the
beginning of the study 131-148 g.
EXPOSURE TO THE TEST SUBSTANCE:
The test substance was given by single gavage to groups of
rats at various dose levels as a 30% aqueous solution. 10
male and 10 female rats were used per dose level.
The LD50 was calculated according to the method described by
Litchfield-Wilcoxon.
Reliability: (2) valid with restrictions
post exposure observation period only 7 days, no further
information on purity, limited documentation
Flag:
Critical study for SIDS endpoint
08-DEC-2003 (111)
Type:
Species:
Value:
LD50
rat
= 2840 mg/kg bw
Reliability: (4) not assignable
secondary citation
17-MAR-2003 (112)
Type:
LD50
146
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